An interventional study of blood cell analysis, blood gas surveillance, chest radiograph and echocardiography in Lung Injury, Acute, sponsored by Yangzhou University. Completed at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-11-14.
Sponsored by Yangzhou University · Not applicable, Interventional, and Diagnostic
More than 2 million patients worldwide receive heart surgery every year, majority of these surgical patients will undergo cardiopulmonary bypass. However, the incidence of postoperative acute lung injury due to cardiopulmonary bypass is still as high as 20% to 35%. According to clinical experience, the earlier lung damage is detected, the more successful the treatment will be. On the basis of traditional detection, the investigators found a new indicator, serum calpains, which are easy to obtain and have certain specificity. Importantly, they can predict postoperative acute lung injury within 1 hour after cardiac surgery. It is meaningful that this indicator can provide clinicians with early decision-making advice and immediate treatment for patients who may be at risk.
399 studies on the registry are indexed under Lung Injury; 50 are open to participants now.
This study's enrollment of 100 is above the median of 53 across 239 interventional studies indexed under Lung Injury.
Browse Lung Injury studies →Yangzhou University is the lead sponsor of 40 studies on the registry; 5 are open to participants now.
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Diagnostic Test: blood cell analysis, blood gas surveillance, chest radiograph and echocardiography
Diagnostic Test: blood cell analysis, blood gas surveillance, chest radiograph and echocardiography
Laboratory parameters of all postoperative patients including blood cell analysis, blood gas surveillance, liver, and kidney function alone with chest radiograph and echocardiography were dynamically monitored.
PaO2/FiO2 ratio
The ratio of inspiratory oxygen fraction to oxygen pressure (PaO2/FiO2) was calculated.
Time frame: Change from beginning of CPB to 48 h after CPB
lung-injury scores
A structured tutorial was used to establish consensus in the interpretation of radiographs for radiographic lung-injury scores, range from 0 to 4. 0: No alveolar consolidation; 1: Alveolar consolidation confined to 1 quadrant; 2: Alveolar consolidation confined to 2 quadrants 3: Alveolar consolidation confined to 3 quadrants; 4: Alveolar consolidation in all 4 quadrants. The higher scores mean a worse outcome.
Time frame: The 24 and 48 hours after CPB
Perioperative serum calpains' concentrations
Serial serum samples were obtained and measured by using a fluorometric kit (Abcam, Cambridge, UK) according to the manufacturer's protocol.
Time frame: The day before CPB and 1, 12, 24, 48 hours after CPB
This study is completed, as verified in Oct 2022. You cannot join it, but the record below documents what was studied.
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Yangzhou University