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CompletedNCT05610020Updated Nov 8, 2022

Heparin Binding Protein as a Prognostic Biomarker of Sepsis Severity

An observational study in Sepsis and HBP, sponsored by Ain Shams University. Completed at 1 site in Egypt. Open to participants aged 20 Years to 70 Years. Per ClinicalTrials.gov, last updated 2022-11-08.

Sponsored by Ain Shams University · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
55
Ages
20 Years to 70 Years
Sex
All
01

Study summary

the aim of the study is to correlate between the severity of sepsis and serum heparin binding protein in the patients admitted to ICU with sepsis., and detect its value as a prognostic biomarker in sepsis

02

Conditions studied

  • Sepsis
  • HBP

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03

In context

Sepsis

1,899 studies on the registry are indexed under Sepsis; 462 are open to participants now.

This study's enrollment of 55 is below the median of 160 across 931 observational studies indexed under Sepsis.

Browse Sepsis studies →

Lead sponsor

Ain Shams University is the lead sponsor of 1,876 studies on the registry; 423 are open to participants now.

Of its 32 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
20 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

adult confirmed septic patients

Inclusion criteria

  • adult whose age between 20 to70 years old
  • patients suffered from sepsis or septic shock (under the third international consensus definition of sepsis and septic shock)

Exclusion criteria

Exclusion Criteria:

  • Any pregnancy female
  • Any patient who is Neutropenic secondary to malignancy
  • Patients who is taking immunosuppressive therapy
  • Patients who is suffering fromHematological malignancy
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
55 participants (actual)
Patient registry
No
Biospecimen retention
Samples without dna
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What researchers measure

Primary outcomes

  1. Evaluate the level of Heparin binding protein in relation to patient clinical improvement measured by SOFA Score

    Correlates the change of the level of Heparin binding protein in ng/ml to the clinical improvement of the patients which is measured by SOFA score

    Time frame: 72 hours after meeting sepsis ceriteria

Secondary outcomes

  1. Heparin binding protein and mortality

    Correlates the change of the level of Heparin binding protein in ng/ml And how can it is used to predict mortality

    Time frame: 28 days after meeting sepsis ceriteria

07

Study locations

1 site
  • Omar Hamdy
    Minya, 61511, Egypt
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 8, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT05610020
Lead sponsor
Ain Shams University
Responsible party
Omar Hamdy (Specialist intensive care medicine, Ain Shams University) — Principal investigator
First posted
Nov 8, 2022
Start date
Oct 1, 2021
Primary completion
Aug 1, 2022
Completion
Oct 1, 2022
Last update
Nov 8, 2022

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2022. You cannot join it, but the record below documents what was studied.

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