An observational study in Large Artery Stiffness, Aortic Disease and Aortic Stenosis, sponsored by Heinrich-Heine University, Duesseldorf. Recruiting at 1 site in Germany. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-01-10.
Sponsored by Heinrich-Heine University, Duesseldorf · Observational
The aorta distributes cardiac stroke volume into the whole body through its finetuned conductance function, that is propagation and modulation of flow pattern. Physicomechanic properties of the aortic wall assure continuous and homogenous blood flow distribution to organs. The physicomechanic properties of the aortic wall are heterotopic: The collagen/elastin ratio doubles in the abdominal aorta as compared to the thoracic aorta. Malfunction of aortic conduction due to large artery stiffening (LAS) leads to premature wave reflection and excess pulsatility which translate into organ damage in low-resistance beds. The regional heterogeneity of aortic physicomechanic properties and their histomorphological substrate leading to altered regional hemodynamics are not well investigated.
Within the PHaRAo population, there is a spectrum of higher and lower risk patients. The aim of this cohort study is to collect prospectively and systematically clinical research data from PHaRAo patients. This cohort study is an open-end observational study to identify master switches in aortic disease
222 studies on the registry are indexed under Aortic Aneurysm; 63 are open to participants now.
This study's planned enrollment of 300 is above the median of 150 across 117 observational studies indexed under Aortic Aneurysm.
Browse Aortic Aneurysm studies →Heinrich-Heine University, Duesseldorf is the lead sponsor of 180 studies on the registry; 54 are open to participants now.
Compared within Aortic Aneurysm, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Aortic Diseases. The counts are of registry records indexed under each term, refreshed daily. How we classify →
healthy volunteers, patients with aortic stenosis, patients with aortic aneurysm
apparently healthy volunteers
Inclusion Criteria:
Exclusion Criteria:
Patients with Aortic Stenosis
Inclusion Criteria:
Exclusion Criteria:
Inclusion Criteria:
Exclusion Criteria:
Other: Collection of Clinical Data
Other: Collection of Clinical Data
Other: Collection of Clinical Data
prospectively and systematically collection of clinical research data from apparently healthy volunteers and patients with aortic stenosis and aneurysms
Progressive accelerated Large Artery Stiffening
measured by CMR
Time frame: 5 years
Development of Aortic Aneurysm
measured by CMR
Time frame: 5 years
Progressive accelerated Large Artery Stiffening
measured by tonometry
Time frame: 5 years
Diastolic Dysfunction
measured by CMR
Time frame: 5 years
Diastolic Dysfunction
measured by echocardiography
Time frame: 5 years
Ejection Rate and Ejection Time
measured by CMR
Time frame: 5 years
Ejection Rate and Ejection Time
measured by echocardiography
Time frame: 5 years
Flow encoded regional MRI metrics
measured by CMR
Time frame: 5 years
Plan to share: No
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Heinrich-Heine University, Duesseldorf →