Status unknownNCT05591885Updated Apr 28, 2023

Nutrilite Memory Builder on the Improvement of Cognitive Function

An interventional study of Study product group (Nutrilite Memory Builder) and Placebo group in Cognitive Function, sponsored by Amway (China) R&D Center. Status unknown at 1 site in China. Open to participants aged 40 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-04-28.

Sponsored by Amway (China) R&D Center · Not applicable, Interventional, and Other

The sponsor has not verified this record recently (last verified Apr 2023), so the status shown — last known as Recruiting — may be out of date.

Phase: Not applicable
Study type: Interventional
Enrollment: 100
Allocation: Randomized
Ages: 40 Years to 75 Years
Sex: All

Study summary

Its a randomized controlled trial, to evaluate the effect of NUTRILITE Memory Builder on the improvement of cognitive function in middle-aged and elderly people.

Read the detailed description

The study center will recruit 100 male or female subjects aged 40-75 years as needed. Enrolled subjects will be divided into 2 groups, with 50 subjects in each group.

Study subjects will be administrated with either the Amway product or a placebo for three months (12 weeks). At least 42 subjects in each group (84 in total) are required to complete the study.

Conditions studied

Cognitive Function

Keywords

MMSE
MoCA
WMS-R
Cognitrax Test

In context

Lead sponsor

Amway (China) R&D Center is the lead sponsor of 7 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 40 Years to 75 Years
Sexes eligible: All
Accepts healthy volunteers: Yes

Inclusion criteria

Males or females, 40-75 years old (with age groups of 40-60 years and 61-75 years as close as possible to a 1:1 ratio);
Healthy subjects with no underlying diseases and no drug treatment at the time of screening;
Meet the requirements of MMSE scores of 24-29;
Be willing to comply with all study requirements and procedures;
Agree to sign the informed consent form.

Exclusion criteria

Exclusion Criteria:

Participated in similar clinical trials in the last 6 months;
Have mental illness or disorders of consciousness and behavior;
Have severe chronic diseases and are currently under treatment with drugs;
Have taken drugs that can affect cognitive function (such as first-generation antihistamines, benzodiazepines, sedatives, opiates, stabilizers, antidepressants, cholinergic drugs, anticholinergic drugs, prescription anti-inflammatory drugs) and any other regularly influential agents.
Had flu/virus symptoms within 3 months before screening;
Received within 3 months before screening or currently receiving medical or nutritional treatments, including protein supplementation or substances that provide exercise capacity;
Had weight gain or weight loss of more than 5kg within 3 months before screening;
Have a history of hospitalization within 3 months before screening;
Have any of the following medical history or have been clinically diagnosed with any of the following diseases: obvious gastrointestinal disorders; liver, kidney, endocrine, blood, respiratory and cardiovascular diseases. These may affect the assessment of product efficacies.
Have high daily alcohol consumption, i.e. more than 14 bottles of beer (350 ml/bottle) or wine (180 ml/bottle) per week;
The PI believes that the subjects cannot fully cooperate with the trial arrangement.

Study design

Phase: Not applicable
Primary purpose: Other
Allocation: Randomized
Intervention model: Parallel assignment
Masking: Single (Investigator)
Enrollment: 100 participants (estimated)

Study arms

Experimental
Study product gruop
Nutrilite Memory Builder Ingredients (Cistanche deserticola extract, Ginkgo biloba extract, glucose, microcrystalline cellulose, corn starch, etc.) 60 Tablets / bottle
Dietary Supplement: Study product group (Nutrilite Memory Builder)
Placebo comparator
Placebo group
Ingredients (glucose, microcrystalline cellulose, corn starch, caramel pigment, etc.) 60 Tablets / bottle
Dietary Supplement: Placebo group

Interventions

Dietary supplementStudy product group (Nutrilite Memory Builder)
During study intervention, subjects are required to take the randomly assigned study product following the instructions.Take one tablet twice daily with meals.
Dietary supplementPlacebo group
During study intervention, subjects are required to take the randomly assigned placebo following the instructions.Take one tablet twice daily with meals.

What researchers measure

Primary outcomes

Mini-Mental State Examination
Change of mental status after 90-days product intervention
Time frame: endpoint( day 90)
Wechsler Memory Scale RC
Change of memory after 90-days product intervention. A complete set of memory evaluation tools with 10 subscales measured three aspects of participants' long-term, short-term and instantaneous memory, which added three sub-tests to WMS. Among them, there are 3 sub-tests of long-term memory, namely personal experience, orientation, and numerical order; There are 6 sub-tests for short-term memory, namely visual rerecognition, picture recall, visual regeneration, associative learning, touch, and comprehension; Instantaneous memory has only 1 sub-test, i.e. reciting numbers in a forward and backward manner. Scoring uses the Memory Quotient (MQ) method, where higher MQ values indicate better memory ability.
Time frame: endpoint( day 90)

Secondary outcomes

Quality of Life Scale
Record the data of the subjects' life quality,The quality score is 60 points, the good is 51-60 points, the good is 41-50 points, the general is 31-40 points, the poor is 21-30 points, and the quality of life is \< 20 points.
Time frame: baseline(day 0)/interim ( day 45)/endpoint( day 90)
Activities of Daily Living Scale
Record the data of the subjects' activities of daily living；The scoring results can be divided into four grades: grade 0=self-care: 100 points, good ability of daily living activities, without help from others grade=mild dysfunction: 99-61 points, able to independently complete some daily activities, but need help; Level II=moderate dysfunction: 60-41 points, need great help to complete activities of daily living Level III=severe dysfunction: ≤ 40 points, most activities of daily living can not be completed completely need care.
Time frame: baseline(day 0)/interim ( day 45)/endpoint( day 90)
Verbal Memory Test of Cognitrax Test
Use the official website(www.cnsvs.com) to test subjects' verbal memory
Time frame: baseline(day 0)/interim ( day 45)/endpoint( day 90)
Finger Tapping Test of Cognitrax Test
Use the official website(www.cnsvs.com) to test subjects' finger movement
Time frame: baseline(day 0)/interim ( day 45)/endpoint( day 90)
Symbol Digit Coding Test of Cognitrax Test
Use the official website(www.cnsvs.com) to test subjects' processing speed, working memory, visuospatial processing, and attention.
Time frame: baseline(day 0)/interim ( day 45)/endpoint( day 90)
Stroop Test of Cognitrax Test
Use the official website(www.cnsvs.com) to test subjects' memory and attention.
Time frame: baseline(day 0)/interim ( day 45)/endpoint( day 90)
Shifting Attention Test of Cognitrax Test
Use the official website(www.cnsvs.com) to test subjects' measures the subject s ability to shift from one instruction set to another quickly and accurately.
Time frame: baseline(day 0)/interim ( day 45)/endpoint( day 90)
Continuous Performance Test of Cognitrax Test
Use the official website(www.cnsvs.com) to test subjects' different aspects of attention.
Time frame: baseline(day 0)/interim ( day 45)/endpoint( day 90)
Four-part Continuous Performance Test of Cognitrax Test
Use the official website(www.cnsvs.com) to test subjects' cognitive ability.
Time frame: baseline(day 0)/interim ( day 45)/endpoint( day 90)
Montreal Cognitive Assessment;
Test Cognitive Ability
Time frame: baseline(day 0)/interim ( day 45)/endpoint( day 90)
72-hrs Food Recall
72-hours food recall of subjects
Time frame: baseline(day 0)/interim ( day 45)/endpoint( day 90)
Sport Frequency Questionnaire
Record the exercise frequency and duration within one week, without any score.
Time frame: baseline(day 0)/interim ( day 45)/endpoint( day 90)
Blood
blood routine test （red blood cell count, white blood cell count, platelet count，hemoglobin）
Time frame: baseline(day 0)/endpoint( day 90)
Urine
Urine routine test（Leukocyte, Urine Protein, Ketone Body）
Time frame: baseline(day 0)/endpoint( day 90)

Study locations

1 of 1 sites recruiting

Kangrong Clinic
Jinhua, Zhejiang 321041, China
- Charlie Zhang, MD · Contact · charlie.zhang@sprimmedical.com · +8613901981272
- Wenan Wang, Professor · Principal investigator
Recruiting

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Apr 28, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT05591885
Lead sponsor: Amway (China) R&D Center
Responsible party: Sponsor
First posted: Oct 24, 2022
Start date: Oct 24, 2022
Primary completion: May 31, 2023 (estimated)
Completion: May 31, 2023 (estimated)
Last update: Apr 28, 2023

Study contacts

Wenan Wang, MD

Contact

13611641232@163.com

13611641232

Wenan Wang, MD

principal investigator · Shanghai Jiao Tong University School of Medicine

Oversight

Data monitoring committee: Yes
FDA-regulated drug: No
FDA-regulated device: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Apr 2023. You cannot join it, but the record below documents what was studied.

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