An interventional study of Drink in Cognitive Change, sponsored by University of Memphis. Completed at 1 site in United States. Open to participants aged 40 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-09-26.
Sponsored by University of Memphis · Not applicable, Interventional, and Basic science
The purpose of the present research study is to evaluate the claims about the supplement influencing cognitive function that may impact performance on cognitive task and related biochemical measures. The synergistic administration of Pyrroloquinoline Quinone and molecular Hydrogen (in the form of Alpha Hope) will be evaluated in adults without a diagnosis of disease (i.e., otherwise healthy adults-the population the supplement is marketed to) on certain biochemical markers, subject's self-assessed wellness, and functional measurements determined via computer tests.
Alpha Hope is a dietary supplement that contains Pyrroloquinoline Quinone and Magnesium-which has been shown to generate molecular hydrogen when mixed into water. Both Pyrroloquinoline Quinone and molecular hydrogen have been shown to exhibit antioxidant and anti-inflammatory capacities. Both Pyrroloquinoline Quinone and magnesium are widely used as dietary supplements, alone and in combination with other ingredients; however, to our knowledge, this is the first time that these two ingredients have been coupled together within one dietary supplement.
Previous research has demonstrated a wide range of health benefits from Pyrroloquinoline Quinone. Of particular interest, Pyrroloquinoline Quinone has been shown to improve cognition when supplemented at daily dosages similar to that proposed in the present study.
Molecular hydrogen has inherent anti-apoptosis, anti-inflammatory, and anti-oxidation properties and has therefore been studied in numerous animal studies, as well as human studies as a possible treatment for degenerative brain function. One method for generating molecular hydrogen, is using elemental magnesium, which reacts with water to generate molecular hydrogen.
The purpose of the present research study is to evaluate the claims about the supplement influencing cognitive function that may impact performance on cognitive task and related biochemical measures. The synergistic administration of Pyrroloquinoline Quinone and molecular Hydrogen (in the form of Alpha Hope) will be evaluated in adults without a diagnosis of disease -(i.e., otherwise healthy adults- the population the supplement is marketed to) on certain biochemical markers, subject's self-assessed wellness, and functional measurements determined via computer tests.
University of Memphis is the lead sponsor of 44 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Each tablet contains 10 mg PQQ and 40 mg (19% DV) magnesium as well as malic acid, dextrose, adipic acid, citric acid, natural flavor, and blackberry leaf extract
Dietary Supplement: Drink
Same formulation as experimental with 250 mg calcium carbonate replacing the magnesium and PQQ.
Dietary Supplement: Drink
Consume one tablet fully dissolved in 8 ounces. Take 2 tablets per day for adults (morning and evening) for 4 weeks
Digit Symbol Substitution test
Using the response key (at the top of the test), subjects select the corresponding number with a computer mouse that corresponds with the specific symbol displayed on the computer screen to obtain as many correct responses as they can within a set time frame (two minutes)
Time frame: baseline
Digit Symbol Substitution test
Using the response key (at the top of the test), subjects select the corresponding number with a computer mouse that corresponds with the specific symbol displayed on the computer screen to obtain as many correct responses as they can within a set time frame (two minutes)
Time frame: 4 week timepoint
AX-Continuous Performance Test
Subject press different keys on a keyboard to indicate if the stimulus is the target (AX) or non-target to measure accuracy and response time
Time frame: baseline
AX-Continuous Performance Test
Subject press different keys on a keyboard to indicate if the stimulus is the target (AX) or non-target to measure accuracy and response time
Time frame: 4 week timepoint
Go/No-Go test
Subjects press a key when Go is displayed and no key when No Go is displayed to test accuracy and reaction time.
Time frame: baseline
Go/No-Go test
Subjects press a key when Go is displayed and no key when No Go is displayed to test accuracy and reaction time.
Time frame: 4 week timepoint
irisin
Irisin is quantified from blood sample
Time frame: baseline
irisin
Irisin is quantified from blood sample
Time frame: 4 week timepoint
brain-derived neurotrophic factor
Brain-derived neurotrophic factor is quantified from blood sample
Time frame: baseline
brain-derived neurotrophic factor
Brain-derived neurotrophic factor is quantified from blood sample
Time frame: 4 week timepoint
Fibroblast growth factor 21
Fibroblast growth factor 21 factor is quantified from blood sample
Time frame: baseline
Fibroblast growth factor 21
Fibroblast growth factor 21 factor is quantified from blood sample
Time frame: 4 week timepoint
Self-reported Wellness Assessment
Subjects report their self-reported wellness using a visual analog scale from 0-10 with 0 being extremely low and 10 being extremely high
Time frame: baseline
Self-reported Wellness Assessment
Subjects report their self-reported wellness using a visual analog scale from 0-10 with 0 being extremely low and 10 being extremely high
Time frame: 4 week timepoint
Blood Pressure
Blood pressure (diastolic and systolic) is measured using an automated machine
Time frame: baseline
Blood Pressure
Blood pressure (diastolic and systolic) is measured using an automated machine
Time frame: 4 week timepoint
Heart Rate
Heart Rate is measured using an automated machine
Time frame: baseline
Heart Rate
Heart Rate is measured using an automated machine
Time frame: 4 week timepoint
This study is completed, as verified in Sep 2023. You cannot join it, but the record below documents what was studied.
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University of Memphis