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Status unknownNCT05585060Updated Nov 22, 2022

The Changes in End Expiratory Lung Impedence Measured by EIT and End Expiratory Lung Volume Measured by Passive Expiratory in Controlled Mechanical Ventilated Exacerbation COPD Patients

An interventional study of the changes of end expiratory lung impedence and the changes of end expiratory lung volume in COPD, sponsored by The First Affiliated Hospital of Guangzhou Medical University. Status unknown at 1 site in China. Open to participants aged 35 Years to 80 Years. Per ClinicalTrials.gov, last updated 2022-11-22.

Sponsored by The First Affiliated Hospital of Guangzhou Medical University · Not applicable, Interventional, and Diagnostic

The sponsor has not verified this record recently (last verified Nov 2022), so the status shown — last known as Recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
10
Allocation
Not applicable
Ages
35 Years to 80 Years
Sex
All
01

Study summary

The pathophysiological characteristics of respiratory failure on exacerbation of chronic pulmonary obstructive disease are the rapid deteriorate of respiratory symptoms, combined with aggravated flow limitation, gas trapping, dynamic pulmonary hyperinflation (DPH), therefore the intrinsic PEEP (PEEPi) increases. It is worthwhile to explore bedside methods to quantify the changes in dynamic pulmonary hyperinflation to guide safe and effective mechanical ventilation in airflow limited patients.

Read the detailed description

The study hypothesizes that the electrical impedence tomography (EIT) measured the changes of end expiratory lung impedence (△EELI） could accurately predict the changes of end expiratory lung volume （△EELV） measured by passive expiratory in controlled mechanical ventilated exacerbation COPD patients. The research intended to conduct a research to explore the relationship between △EELI and △EELV induced by external PEEP changes in ventilated exacerbation COPD patients.

02

Conditions studied

  • COPD

Keywords

  • COPD
  • dynamic pulmonary hyperinflation
  • mechanical ventilation
  • end expiratory lung impedence
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In context

Lead sponsor

The First Affiliated Hospital of Guangzhou Medical University is the lead sponsor of 158 studies on the registry; 65 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
35 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • 2022.7-2023.1 exacerbation COPD invasive ventilated patients admitted to the first affiliated Guangzhou medical university; 35 to 80 years old; in stable condition judged by clinicians

Exclusion criteria

Exclusion Criteria:

  • SpO2\<88%; instable hemodynamic (MAP\<65mmHg；Norepinephrine> 0.1ug/kg.min); pregnancy; 4 hour intravenous diuretics use before research; chest deformity and trauma, subpleural pulmonary bulla; implanted electronic devices(cardiac pacemaker, implantable cardioversion defibrillator,ect); tumour or other organ dysfunction; refuse to signature the informed consent
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Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
10 participants (estimated)

Study arms

  • Experimental
    PEEP titration for mechanical ventilated AECOPD patients

    Pre- and post-self-controlled trials for invasive mechanical ventilated AECOPD patients during PEEP titration.

    Diagnostic Test: the changes of end expiratory lung impedence · Diagnostic Test: the changes of end expiratory lung volume

Interventions

  • Diagnostic testthe changes of end expiratory lung impedence

    the changes of end expiratory lung impedence measured by EIT

    Also known as: △EELI

  • Diagnostic testthe changes of end expiratory lung volume

    the changes of end expiratory lung volume measured by apnea method

    Also known as: △EELV

06

What researchers measure

Primary outcomes

  1. the changes of end expiratory lung volume

    measured by EIT and IC maneuver

    Time frame: 10 minutes

Secondary outcomes

  1. intrinsic PEEP

    measured by Esophageal balloon catheters

    Time frame: 10 minutes

07

Study locations

1 of 1 sites recruiting
  • The First Affiliated Hospital of Guangzhou Medical
    Guangzhou, Guangdong 510120, China
    Recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 22, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05585060
Lead sponsor
The First Affiliated Hospital of Guangzhou Medical University
Responsible party
FuWei (Principal Investigator, The First Affiliated Hospital of Guangzhou Medical University) — Principal investigator
First posted
Oct 18, 2022
Start date
Sep 13, 2022
Primary completion
Oct 8, 2023 (estimated)
Completion
Oct 8, 2023 (estimated)
Last update
Nov 22, 2022

Study contacts

Wei Fu, MD
Contact
hooray_009@163.com
+8602083062882
Rongchang Chen, PhD
study chair · The First Affiliated Hospital of Guangzhou Medical University

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Nov 2022. You cannot join it, but the record below documents what was studied.

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