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CompletedNCT05583084Updated Oct 17, 2022

Sex-unique Disparities in Survival and Resuscitation After Out-of-hospital Cardiac Arrest - a Danish Analysis

An observational study in Out-Of-Hospital Cardiac Arrest, sponsored by Prehospital Center, Region Zealand. Completed. Per ClinicalTrials.gov, last updated 2022-10-17.

Sponsored by Prehospital Center, Region Zealand · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
27,000
Sex
All
01

Study summary

The goal of this observational study is to investigate characteristics in out-of-hospital cardiac arrests (OHCA) related to sex differences.

The main questions it aims to answer are:

  • are there possible differences in help provision by bystanders, cardiopulmonary resuscitation (CPR), pre-hospital treatment by emergency medical services (EMS)?
  • are there differences in the presence of shockable initial rhythm (SIR) and survival rates after OHCA at successive stages of treatment? Researchers will compare all emergency medical services treated resuscitations in Denmark between 2016 and 2021 to see if there are possible differences between sexes.
Read the detailed description

This analysis will be based on data from the national electronic based Danish OHCA registry. Data on OHCAs with resuscitative attempts in Denmark have been collected in the electronic based Danish Medical Service report system since 2016. The registry covers detailed data including the EMS report, executive entries, and advanced text searches of prehospital charts. All cases go through an elaborate validation process where all identified events are read through manually by an external verification team. This ensures high quality of data, collected according to the Utstein recommendations, throughout the approximately 5400 cases of OHCA in Denmark annually. During this verification process, supplementary sources of data are linked to each OHCA, among others information about survival, localization, initiation of bystander CPR and EMS personnel operation.

02

Conditions studied

  • Out-Of-Hospital Cardiac Arrest

Keywords

  • sex differences
  • ohca
  • women
  • SIR
  • CPR
03

In context

Heart Arrest

966 studies on the registry are indexed under Heart Arrest; 227 are open to participants now.

This study's enrollment of 27,000 is above the median of 200 across 383 observational studies indexed under Heart Arrest.

Browse Heart Arrest studies →

Lead sponsor

Prehospital Center, Region Zealand is the lead sponsor of 16 studies on the registry; 4 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Sampling method
Non-probability sample

Study population

All emergency medical services treated resuscitations in Denmark between 2016 and 2021 registered in the national electronic based Danish OHCA registry

Inclusion criteria

  • All emergency medical services treated resuscitations in Denmark between 2016 and 2021

Exclusion criteria

Exclusion Criteria:

  • Patients that are found dead at emergency medical service arrival, with sure death indicators such as rigor mortis or livores.
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
27,000 participants (actual)
Patient registry
No

Interventions

  • OtherInvestigation
06

What researchers measure

Primary outcomes

  1. 30-days survival

    Records on survival after 30 days from cardiac arrest

    Time frame: 30 days from OHCA

Secondary outcomes

  1. Cardiopulmonary Resuscitation (CPR)

    Whether or not CPR was performed on the patient

    Time frame: 2016-2021

  2. Presence of shockable initial rhythm (SIR)

    Whether or not a schockable intial rhythm was recorded

    Time frame: 2016-2021

  3. Return of spontaneous circulation (ROSC) at any time

    Whether or not there was return of spontaneous circulation at any time

    Time frame: 2016-2021

07

Study locations

No study locations are listed for this record.

08

References and documents

Study documents

  • Study protocol · Oct 5, 2022

Documents are hosted by the registry — open the source record to download them.

Individual participant data

Plan to share: Undecided

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 17, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05583084
Lead sponsor
Prehospital Center, Region Zealand
Responsible party
Eleonora Casarini (Fellow researcher and medical student, Prehospital Center, Region Zealand) — Principal investigator
First posted
Oct 17, 2022
Start date
Jan 1, 2016
Primary completion
Dec 31, 2021
Completion
Dec 31, 2021
Last update
Oct 17, 2022
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2022. You cannot join it, but the record below documents what was studied.

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