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CompletedNCT05582564COVANEWUpdated Oct 17, 2022

The Effect of Newspaper Reporting on COVID-19 Vaccine Hesitancy: a Randomised Controlled Trial

An interventional study of abstract vs concrete texts in Vaccine Hesitancy, sponsored by University of Bari Aldo Moro. Completed at 1 site in Italy. Open to participants aged 18 Years to 64 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-10-17.

Sponsored by University of Bari Aldo Moro · Not applicable, Interventional, and Other

From the registry’s dates

  • Registered 1 year 4 months after the study started (first participant enrolled Jun 2021, registered Oct 2022).
Phase
Not applicable
Study type
Interventional
Enrollment
1,068
Allocation
Randomized
Ages
18 Years to 64 Years
Sex
All
01

Study summary

COVID-19 vaccine hesitancy can be observed at different rates in different countries. 1,068 people were surveyed in France and Italy to inquire about individual potential acceptance, focusing on time preferences, in a risk-return framework: having the vaccination today, in a month, and in 3 months; perceived risks of vaccination and COVID-19; and expected benefit of the vaccine. A randomized controlled trial was conducted to understand how everyday stimuli, such as fact-based news about vaccines, impact on audience acceptance of vaccination. The main experiment involved two groups of participants and two different articles about vaccine-related thrombosis taken from two Italian newspapers. One article used a more abstract description and language, and the other used a more anecdotical description and concrete language; each group read only one of these articles. Two other groups were assigned categorization tasks; one was asked to complete a concrete categorization task and the other an abstract categorization task.

Read the detailed description

The goal of this RCT is to learn how journalistic news can affect vaccine hesitancy. 2 cohorts of unvaccinated individual, one Italian, one French. 5 arms design:

  1. participants reading a fact-based newspaper article written in an abstract language
  2. participants reading a fact-based newspaper article written in a more concrete language
  3. participants performing abstract categorization task
  4. participants performing concrete categorization task
  5. control group answering questionnaire

Research questions:

i) Does a more abstract vs concrete language increase the willingness to receive the vaccine? ii) Does a more abstract vs concrete mindset increase the willingness to receive the vaccine? iii) Is a gender effect detectable?

02

Conditions studied

  • Vaccine Hesitancy

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Keywords

  • vaccine hesitancy
03

In context

Vaccination Hesitancy

121 studies on the registry are indexed under Vaccination Hesitancy; 14 are open to participants now.

This study's enrollment of 1,068 is above the median of 516 across 98 interventional studies indexed under Vaccination Hesitancy.

Browse Vaccination Hesitancy studies →

Lead sponsor

University of Bari Aldo Moro is the lead sponsor of 30 studies on the registry; 13 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 64 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

unvaccinated individuals

Exclusion criteria

Exclusion Criteria:

vaccinated individuals

05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
1,068 participants (actual)

Study arms

  • Other
    concrete text

    Italian and French unvaccinated cohorts (n= 164; n=163)

    Other: abstract vs concrete texts

  • Other
    abstract text

    Italian and French unvaccinated cohorts (n=155; n=153)

    Other: abstract vs concrete texts

  • Other
    abstract task

    Italian and French unvaccinated cohorts (n=54; n=55)

    Other: abstract vs concrete texts

  • Other
    concrete task

    Italian and French unvaccinated cohorts (n=55; n=56)

    Other: abstract vs concrete texts

  • Other
    control

    Italian and French unvaccinated cohorts (n=103; n=110)

    Other: abstract vs concrete texts

Interventions

  • Otherabstract vs concrete texts

    The main experiment involved two groups of participants and two different articles about vaccine-related thrombosis taken from two Italian newspapers. One article used a more abstract descriptive style and language, while the other used a more anecdotical style and concrete language: each group read only one of these articles. Both articles are the same length and describe an episode of vaccine-related thrombosis. The abstract text uses a more formal and impersonal language, reporting more scientific considerations; the concrete text uses a more familiar and emotional style and provides a more anecdotical description of the case. Texts were also weighted according to a concreteness semantic vocabulary. French received translated versions.Two other groups were assigned categorization tasks; one was asked to complete a concrete categorization task and the other an abstract categorization task.

    Also known as: abstract vs concrete tasks

06

What researchers measure

Primary outcomes

  1. vaccine hesitancy; number of participants accepting the vaccination

    revealed preferences

    Time frame: same day

07

Study locations

1 site
  • University of Bari Aldo Moro
    Bari, 70121, Italy
08

References and documents

Publications

  • Liberman N, Trope Y. Traversing psychological distance. Trends Cogn Sci. 2014 Jul;18(7):364-9. doi: 10.1016/j.tics.2014.03.001. Epub 2014 Apr 10. PubMed 24726527 ↗
  • Trope Y, Liberman N. Temporal construal. Psychol Rev. 2003 Jul;110(3):403-21. doi: 10.1037/0033-295x.110.3.403. PubMed 12885109 ↗
  • Loomba S, de Figueiredo A, Piatek SJ, de Graaf K, Larson HJ. Measuring the impact of COVID-19 vaccine misinformation on vaccination intent in the UK and USA. Nat Hum Behav. 2021 Mar;5(3):337-348. doi: 10.1038/s41562-021-01056-1. Epub 2021 Feb 5. PubMed 33547453 ↗
  • MacDonald NE; SAGE Working Group on Vaccine Hesitancy. Vaccine hesitancy: Definition, scope and determinants. Vaccine. 2015 Aug 14;33(34):4161-4. doi: 10.1016/j.vaccine.2015.04.036. Epub 2015 Apr 17. PubMed 25896383 ↗

Individual participant data

Plan to share: No — No personal data have been collected. Individual responses to the questionnaire will be shared without personal information of respondents on a public repository.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Jun 2021 to primary completion in Jun 2021, 0 months.

Of 82 non-industry interventional studies with no phase under Vaccination Hesitancy, half reached primary completion within 6 months of starting (the median), counting those still running; a quarter within 3 and three quarters within 14. This study's 0 months is below that.

Counting every sponsor, half of 83 studies reached it within 5 months; a quarter within 2 and three quarters within 14.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 13, 2022
First posted
Oct 17, 2022
StartActual
Jun 2, 2021
Primary completionActual
Jun 20, 2021
CompletionActual
Jan 31, 2022
Last update
Oct 17, 2022
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Oct 17, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05582564
Lead sponsor
University of Bari Aldo Moro
Responsible party
Anna Rinaldi (Assistant Professor, University of Bari Aldo Moro) — Principal investigator
First posted
Oct 17, 2022
Start date
Jun 2, 2021
Primary completion
Jun 20, 2021
Completion
Jan 31, 2022
Last update
Oct 17, 2022

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Oct 2022. You cannot join it, but the record below documents what was studied.

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