An interventional study of Autogenous Tooth Transplantation and Alveolar Prf graft in Tooth Loss, Tooth Diseases and Reimplant; Complications, sponsored by University of Bari Aldo Moro. Recruiting at 1 site in Italy. Open to participants aged 10 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-06.
Sponsored by University of Bari Aldo Moro · Not applicable, Interventional, and Treatment
Autogenous tooth transplantation (autotransplantation) represents a biologically valid alternative to implant therapy, particularly in young patients where implant placement is contraindicated due to ongoing skeletal growth. This approach preserves alveolar bone volume, maintains periodontal proprioception, and allows physiological adaptation over time.
One of the main limitations of autotransplantation in teeth with complete root formation is the absence of pulpal revascularization following apical closure, which frequently leads to pulp necrosis and the subsequent need for endodontic treatment. Root canal therapy may compromise the structural integrity of the tooth and negatively affect long-term outcomes.
The combined use of simulated apical patency and autologous PRF is expected to enhance pulpal revascularization, reduce the incidence of pulp necrosis, and improve the biological and clinical outcomes of autogenous tooth transplantation in teeth with complete root formation.
This protocol aims to expand the indications for autogenous tooth transplantation by introducing a biologically driven approach that combines surgical and regenerative techniques. The use of autologous PRF may represent a valuable adjunct in improving healing and long-term success in challenging clinical scenarios.
165 studies on the registry are indexed under Tooth Loss; 44 are open to participants now.
This study's planned enrollment of 5 is below the median of 30 across 120 interventional studies indexed under Tooth Loss.
Browse Tooth Loss studies →University of Bari Aldo Moro is the lead sponsor of 30 studies on the registry; 13 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Autotransplantation will be performed in selected cases with favorable biological and functional prognosis, including:
Exclusion Criteria:
Smoking of more than 15 cigarettes a day
•. Untreated periodontal disease
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients presenting with hopeless teeth
Procedure: Autogenous Tooth Transplantation · Procedure: Alveolar Prf graft
After atraumatic extraction of the donor tooth, a simulated apical opening will be created using rotary instruments to induce apical patency and replicate the biological conditions of an open apex, potentially favoring pulpal revascularization.
To enhance clot formation and promote angiogenesis and tissue regeneration, autologous platelet-rich fibrin (PRF) will be used in the recipient site. PRF Collection and Preparation * Prior to surgery, peripheral venous blood will be collected from the patient using sterile tubes without anticoagulants. * The blood samples will be immediately processed using a standardized centrifugation protocol, allowing the separation of a fibrin matrix enriched with platelets and leukocytes. * After centrifugation, the PRF clot will be gently removed and prepared under sterile conditions for clinical use. PRF Placement * The autologous PRF will be placed directly into the recipient alveolus before positioning the donor tooth. * The PRF matrix will act as a biological scaffold, promoting clot stabilization, neovascularization, and early healing of the periodontal and pulpal tissues.
Resporption
Rx to evalue internal or external root resorption. Present or Not.
Time frame: 1 month, 3 months, 6 months, 1 year, 2 years
Vitality
Pulp vitality will be assessed during follow-up using standardized sensibility tests. ( electric test). Vitality : Yes or None
Time frame: 1 month, 3 months, 6 months, 1 year, 2 years
Mobility
Mobility Test. Grade I, Grade II or Grade III
Time frame: 1 month, 3 months, 6 months, 1 year, 2 years
Inflammation
signs of inflammation will be monitored. Blood on Probing: Yes or None
Time frame: 1 month, 3 months, 6 months, 1 year, 2 years
periodontal health
Periodontal Chart (mm). 6 point for each tooth.
Time frame: 1 month, 3 months, 6 months, 1 year, 2 years
bone remodeling
Assess periodontal integration and bone remodeling by Rx. Comparing Rx.
Time frame: 1 month, 1 year, 2 years
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University of Bari Aldo Moro