An observational study in Dry Socket, sponsored by Septodont. Completed at 16 sites in 2 countries. Open to participants aged 5 Years and older. Per ClinicalTrials.gov, last updated 2026-05-14.
Sponsored by Septodont · Observational
Alveogyl (Septodont, Saint-Maur-des-Fossés - France) is a Medical Device used as dressing in case of dry socket.
ALVE study is a clinical investigation measuring Alveogyl performance and safety in patients with post-extraction dry socket.
The study takes place in India and in France where Alveogyl is already marketed, since 2010 in France and since 2014 in India .
46 studies on the registry are indexed under Dry Socket; 10 are open to participants now.
Browse Dry Socket studies →Septodont is the lead sponsor of 11 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with a dry socket occuring after the extraction of a permanent tooth (mature or immature).
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Hypersensitivity
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Study patients are patients with post-extraction dry socket.
Device: Alveogyl
The patients will be treated by Alveogyl. Global treatment protocol (curettage, cleaning, local anaesthesia etc.) of the dry socket is at the discretion of the Investigator. Alveogyl is used as an alveolar dressing. Placement of Alveogyl (about 0.2 g of paste) into the dental socket is done according to its instruction for use by a dental professional only.
Pain Using a Visual Analog Scale (VAS : 0-10)
Patients with no pain or mild pain at Day7 The pain is measured by patients in a diary using a Visual Analogue Scale (VAS: 0-10 mm; 0 no pain - 10 maximum pain) 7 days after treatment with Alveogyl.
Time frame: 7 days post-treatment
Analgesic Use
Patient reporting a painkiller intake. The patient will report in a diary the intake of analgesic use at 3 and 5 days after treatment with Alveogyl
Time frame: 3 and 5 days post-treatment
Healing of the Alveolar Mucosa
Healing of the alveolar mucosa will be clinically reported by the dentist using le Wound healing index. The Wound Healing Index ranges from 1 (poor healing) to 5 (excellent healing), with higher scores indicating better gingival wound healing.
Time frame: 7 days post-treatment
Signs of Local Inflammation
Signs of inflammation around the gingival mucosa (oedema, redness, sensitivity) will be reported by the dentist at Day 7 after tratment with Alveogyl
Time frame: 7 days post-treatment
Antiseptic Effect
Any clinical signs such as gum pain, swollen gum lining, fever, halitosis,...) will be reported by the dentist
Time frame: 7 days post-treatment
Hemostasis
Presence or absence of bleeding in the socket.
Time frame: Immediately after Alveogyl placement and Day 7 after treatment
Complication Rate
Adverse events occuring within 7 days after treatment
Time frame: From Alveogyl placement to 7 days post-treatment
| Milestone | Study Population |
|---|---|
| Started | 120 |
| Completed | 115 |
| Not completed | 5 |
Patients with no pain or mild pain at Day7 The pain is measured by patients in a diary using a Visual Analogue Scale (VAS: 0-10 mm; 0 no pain - 10 maximum pain) 7 days after treatment with Alveogyl.
| Participants | Study Population |
|---|---|
| Success : Patients with no pain or mild pain at Day7 (VAS<4) | 106 |
| Failure : Patients with moderate to severe pain at Day 7 (VAS ≥ 4) | 4 |
Patient reporting a painkiller intake. The patient will report in a diary the intake of analgesic use at 3 and 5 days after treatment with Alveogyl
| Participants | PP Population |
|---|---|
| Patient reporting a painkiller intake at 3 days after treatment with Alveogyl — Patient reporting a painkiller intake | 63 |
| Patient reporting a painkiller intake at 3 days after treatment with Alveogyl — Patient not reporting a painkiller intake | 47 |
| Patients reporting a painkiller intake at 5 days after treatment with Alveogyl — Patient reporting a painkiller intake | 20 |
| Patients reporting a painkiller intake at 5 days after treatment with Alveogyl — Patient not reporting a painkiller intake | 90 |
Healing of the alveolar mucosa will be clinically reported by the dentist using le Wound healing index. The Wound Healing Index ranges from 1 (poor healing) to 5 (excellent healing), with higher scores indicating better gingival wound healing.
| Wound healing index Score | Study Population |
|---|---|
| Healing of the Alveolar Mucosa | 4.0 ± 0.8 |
Signs of inflammation around the gingival mucosa (oedema, redness, sensitivity) will be reported by the dentist at Day 7 after tratment with Alveogyl
| Participants | Study Population |
|---|---|
| patients showing signs of inflammation around the gingival mucosa | 19 |
| patients without signs of inflammation around the gingival mucosa | 91 |
Any clinical signs such as gum pain, swollen gum lining, fever, halitosis,...) will be reported by the dentist
| Participants | Study Population |
|---|---|
| Halitosis / bad breath — Yes | 12 |
| Halitosis / bad breath — No | 96 |
| Halitosis / bad breath — Unknown | 2 |
| Fever — Yes | 2 |
| Fever — No | 108 |
| Fever — Unknown | 0 |
| Tenderness of the gingival mucosa — Yes | 24 |
| Tenderness of the gingival mucosa — No | 86 |
| Tenderness of the gingival mucosa — Unknown | 0 |
| Purulent collection in the alveolus and gingival mucosa — Yes | 0 |
| Purulent collection in the alveolus and gingival mucosa — No | 110 |
| Purulent collection in the alveolus and gingival mucosa — Unknown | 0 |
| Pale discoloration of the dry socket — Yes | 17 |
| Pale discoloration of the dry socket — No | 93 |
| Pale discoloration of the dry socket — Unknown | 0 |
Presence or absence of bleeding in the socket.
| Participants | Study Population |
|---|---|
| Presence or absence of bleeding in the socket immediately after Alveogyl placement — Patients without Bleeding | 96 |
| Presence or absence of bleeding in the socket immediately after Alveogyl placement — Patients showing mild bleeding | 13 |
| Presence or absence of bleeding in the socket immediately after Alveogyl placement — Patients showing moderate bleeding | 1 |
| Presence or absence of bleeding in the socket immediately after Alveogyl placement — Patients showing hemorrhagic oozing | 0 |
| Presence or absence of bleeding in the socket 7 days after Alveogyl placement — Patients without Bleeding | 110 |
| Presence or absence of bleeding in the socket 7 days after Alveogyl placement — Patients showing mild bleeding | 0 |
| Presence or absence of bleeding in the socket 7 days after Alveogyl placement — Patients showing moderate bleeding | 0 |
| Presence or absence of bleeding in the socket 7 days after Alveogyl placement — Patients showing hemorrhagic oozing | 0 |
Adverse events occuring within 7 days after treatment
| Participants | Study Population |
|---|---|
| Patients with adverse events | 0 |
| Patients without adverse events | 110 |
Collected over 7 days. Non-serious events are listed at a 0% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Study Population | 0/120 (0%) | 0/120 (0%) | 0/120 (0%) |
| Age, Continuous(years) | Study Population |
|---|---|
| Mean | 42.6 ± 15.2 |
| Sex: Female, Male(Participants) | Study Population |
|---|---|
| Female | 82 |
| Male | 38 |
| Race and Ethnicity Not Collected(Participants) | Study Population |
|---|
| Region of Enrollment(participants) | Study Population |
|---|---|
| France | 30 |
| India | 90 |
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: Undecided
Ran from Dec 2022 to primary completion in Jun 2025, 30 months.
Results were first posted in Feb 2026, 7 months after primary completion.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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