An interventional study of High-flow nasal oxygenation combined with nasopharyngeal airway and Regular nasal cannula combined with nasopharyngeal airway in Gastric Cancer, Gastric Ulcer and Intestinal Cancer, sponsored by RenJi Hospital. Status unknown at 2 sites in China. Open to participants aged 19 Years to 80 Years. Per ClinicalTrials.gov, last updated 2022-09-02.
Sponsored by RenJi Hospital · Not applicable, Interventional, and Prevention
Obesity is associated with adverse airway events including desaturation during deep sedation. Previous studies have suggested that high-flow nasal oxygenation may be superior to regular (low-flow) nasal cannula for prevention of hypoxia during Sedated Gastrointestinal Endoscopy in non-obesity patients. The prerequisite of high-flow nasal oxygenation is keeping airway patency. Our pervious study demonstrated that nasopharyngeal airway has the similar efficacy of jaw-lift. In present study we aimed to determine whether high-flow nasal oxygenation combined with nasopharyngeal airway could reduce the incidence of hypoxia during Sedated Gastrointestinal Endoscopy in obese patients.
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High-flow nasal oxygenation combined with nasopharyngeal airway was used in obese patients who are scheduled to undergo gastrointestinal endoscopy procedures sedated with propofol.
Device: High-flow nasal oxygenation combined with nasopharyngeal airway
Regular nasal cannula combined with nasopharyngeal airway was used in obese patients who are scheduled to undergo gastrointestinal endoscopy procedures sedated with propofol.
Device: Regular nasal cannula combined with nasopharyngeal airway
The patients receive an oxygen flow of 30 L/min for preoxygenation with a high-flow oxygenation device before losing of conscious. At the time of the abolition of the eyelash reflex, the gas flow was increased to 60 L/min with an inspired oxygen fraction 100% and the nasopharyngeal airway was placed.
The patients receive an oxygen flow of 6 L/min for preoxygenation with a regular nasal cannula until the end of procedure. At the time of abolition of the eyelash reflex, the nasopharyngeal airway was placed.
The incidence of hypoxia
Hypoxia refers to 75%≤SpO2\<90%,\<60S
Time frame: Patients will be followed for the duration of hospital stay, an expected average of 2 hours
The incidence of severe hypoxia
Severe hypoxia refers to SpO2\<75% lasting for any time, or 75%≤SpO2\<90%, ≥60s
Time frame: Patients will be followed for the duration of hospital stay, an expected average of 2 hours
The incidence of subclinical respiratory depression
Subclinical respiratory depression refers to 90%≤ SpO2\<95%
Time frame: Patients will be followed for the duration of hospital stay, an expected average of 2 hours
The incidence of other adverse events
Other adverse events recorded by tools proposed by the World Society of Intravenous Anesthesia International Sedation Task Force
Time frame: Patients will be followed for the duration of hospital stay, an expected average of 2 hours
Plan to share: No
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This study is status unknown, as verified in Aug 2022. You cannot join it, but the record below documents what was studied.
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