An interventional study of Knee Extension Exercise and Quiet Rest in Healthy, sponsored by University of Central Florida. Completed at 1 site in United States. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-04-24.
Sponsored by University of Central Florida · Not applicable, Interventional, and Treatment
The primary purpose of this study is to compare immediate changes in pain sensitivity (pressure pain threshold) during quiet rest, low fatigue exercise, and high fatigue exercise.
Participants will attend three sessions. Participants will fill out questionnaires, undergo pain sensitivity testing, and be randomly assigned to complete a high and low fatigue exercise on either the second or third session. During the exercise, participants will complete three sets of a single leg knee extension exercise with weight equivalent to 50% of their 1 repetition maximum until they report either a high or low fatigue level. Immediately before and after each set, the research team will examine immediate changes in sensitivity to pressure (pressure pain threshold).
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Exclusion Criteria:
Participants will complete a single leg knee extension exercise with weight until they report a fatigue level = 3/10 on the Borg Rating of Perceived Exertion. Participants will complete three sets.
Other: Knee Extension Exercise
Participants will complete a single leg knee extension exercise with weight until they report a fatigue level = 8/10 on the Borg Rating of Perceived Exertion. Participants will complete three sets.
Other: Knee Extension Exercise
Participants will rest quietly for two minutes, three sets.
Other: Quiet Rest
Participants will be seated in a Steel Flex machine with weight equal to 50% of their 1 repetition maximum added to the machine. Participants will extend the dominant knee until the assigned fatigue level.
Participants will sit quietly for two minutes, three times.
Change in Pressure Pain Threshold
A digital pressure algometer will be applied to the quadriceps and upper trapezius for two trials each. Participants are instructed to say "stop" or "pain" so the stimulus can be terminated "when the sensation first transitions from pressure to pain" (pain threshold). Participants will rate the pain experienced during the threshold testing using a 101-point numeric pain rate scale (NPRS) anchored with 0= no pain to 100= the most intense pain sensation imaginable immediately following each testing time.
Time frame: Change from baseline immediately after exercise
Temporal Summation
Participants will rate a train of 10 heat pulses using the 101-point numerical pain rating scale
Time frame: Baseline, pre exercise
Heat Pain Threshold
A thermode will gradually increase temperature. Participants will state when the sensation first becomes painful.
Time frame: Baseline, pre exercise
Conditioned Pain Modulation
Pressure pain threshold after an ice water immersion task will be measured.
Time frame: Baseline, pre exercise
International Physical Activity Questionnaire Short Form
This is a self-report measure of physical activity that provides data regarding health-related physical activity.
Time frame: Baseline, pre exercise
Pittsburgh Sleep Quality Index
This is a 10-item questionnaire in which individuals respond to statements regarding sleep quality. A higher score indicates a worse sleep quality.
Time frame: Baseline, pre exercise
Pain Catastrophizing Scale
This is a 13-item questionnaire in which individuals respond to a statement on a five point scale from 0 to 4. Higher scores indicate higher pain catastrophizing levels.
Time frame: Baseline, pre exercise
Fear of Pain Questionnaire 9
This is a 9-item questionnaire in which individuals respond to a statement on a five point scale from 1 to 5. Higher scores indicate higher fear of pain.
Time frame: Baseline, pre exercise
Pain Anxiety Symptom Scale
This is a 20-item questionnaire in which individuals respond to a statement on a six point scale from 0 to 5. Higher scores indicate higher pain-related anxiety.
Time frame: Baseline, pre exercise
Brief Resilience Scale
This is a 6-item questionnaire in which individuals respond to a statement on a five point scale from 1 to 5. Higher scores indicate greater resilience.
Time frame: Baseline, pre exercise
Preference for and Tolerance of the Intensity of Exercise Questionnaire
This is a 16-item questionnaire in which individuals respond to a statement on a five point scale from 1 to 5. Higher scores indicate lower tolerance for the intensity of exercise.
Time frame: Baseline, pre exercise
1-repetition maximum testing
The amount of weight that can be lifted for 1 repetition
Time frame: Baseline, pre exercise
Plan to share: No
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This study is completed, as verified in Apr 2023. You cannot join it, but the record below documents what was studied.
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University of Central Florida