An interventional study of Video Game Vision Training and Perceptual Learning in Amblyopia, sponsored by Nova Southeastern University. Recruiting at 1 site in United States. Per ClinicalTrials.gov, last updated 2025-12-16.
Sponsored by Nova Southeastern University · Not applicable, Interventional, and Treatment
Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast. This study uses psychophysical measures to study neural plasticity in both adults and children with amblyopia.
Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast. Our previous findings (see Publications) show that the adult amblyopic brain is still plastic and malleable, suggesting that active approach is potential useful in treating amblyopia.The goal of this project is to assess the limits and mechanisms of neural plasticity in both normal and amblyopic spatial vision. This study uses psychophysical measures to study neural plasticity in both adults and children with amblyopia. Research participants will be asked to practice a visual discrimination task (perceptual learning) or to play video games with the amblyopic eye for a period of time. A range of visual functions will be monitored during the course of treatment.
189 studies on the registry are indexed under Amblyopia; 41 are open to participants now.
This study's planned enrollment of 180 is above the median of 60 across 137 interventional studies indexed under Amblyopia.
Browse Amblyopia studies →Nova Southeastern University is the lead sponsor of 80 studies on the registry; 18 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 2 (33%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Participants will be required to play video games for a period of time: 1-2 hrs per session, 4-5 sessions/week for \~1-6 months
Behavioral: Video Game Vision Training
Participants will be required to practice a visual discrimination task (e.g. visual acuity, position acuity, contrast sensitivity, \& stereoacuity) for a period of time: 1-2 hrs per session, 4-5 sessions/week for \~1-6 months
Behavioral: Perceptual Learning
Participants will be required to cover the dominant eye during the day in order to push the brain to use the fellow amblyopic eye: 1-2 hrs per session, 4-5 sessions/week for \~1-6 months
Behavioral: Occlusion Therapy
A new approach for improving amblyopic vision using video games
A new approach for improving amblyopic vision with perceptual learning
Conventional treatment for amblyopia
Change in visual acuity before and after the intervention
"Visual acuity", the gold standard for vision testing, will be measured. Participants will be asked to read letters on a LogMAR letter chart. The smallest letters that can be read correspond to visual acuity (e.g., Snellen acuity of 20/20, letter-stroke width = 1 minute of arc).
Time frame: 9 months
Change in stereoacuity before and after the intervention
"Stereoacuity" will be measured psychophysically using a new stereoacuity function test (1.25, 2.5, 5, 10, 15, \& 20 cycles per degree) developed in our previous studies (Li et al 2016). A custom-built 4-mirror haploscope will be used to present a stereogram to each eye. Stereoacuity is the smallest stereo disparity that can be seen in binocular vision (in the unit of seconds of arc, arcsec). The conventional stereoacuity tests (including Randot Stereoacuity Test, Stereofly Test \& Preschool Stereo Test) will also be used to measure stereoacuity. Participants will be asked to wear a pair of 3D glasses and to identify the target 3D pictures at various 3D levels. The smallest 3D disparities that can be seen correspond to stereoacuity (e.g. normal range of stereoacuity: 50 seconds of arc or better).
Time frame: 9 months
Change in contrast sensitivity before and after the intervention
"Contrast sensitivity", the ability to detect low contrast / brightness, will be measured psychophysically for a range of spatial frequencies (1.25, 2.5, 5, 10, \& 20 cycles per degree). Visual stimuli at different contrast levels will be displayed on a monitor screen. The smallest detectable stimulus contrast level will be measured in the unit of cd/m2.
Time frame: 9 months
Change in positional (or Vernier) acuity before and after the intervention
"Positional acuity", the ability to detect a subtle positional offset between visual stimuli, will be measured psychophysically. Visual stimuli with different amount of positional offsets will be displayed on a monitor screen. The smallest detectable stimulus offset will be measured as position acuity, in the unit of seconds of arc.
Time frame: 9 months
Plan to share: No
Started Sep 2022 (actual). Primary completion is estimated for Aug 2029, 83 months after the start.
Of 58 non-industry interventional studies with no phase under Amblyopia, half reached primary completion within 34 months of starting (the median), counting those still running; a quarter within 21 and three quarters within 72. This study's planned 83 months is above that.
Counting every sponsor, half of 71 studies reached it within 33 months; a quarter within 17 and three quarters within 47.
How these figures are worked out, and which studies are left out of them.
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Nova Southeastern University