An observational study in Ultrasound Guidance, sponsored by Tongji Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2022-10-21.
Sponsored by Tongji Hospital · Observational
Studies have shown that the clinical application of ultrasound to measure large blood vessels related parameters has been widely used to assess the blood volume status of patients, with the advantages of simple, non-invasive and non-radioactive, etc. However, these current methods using by ultrasound technology such as diameter and collapsibility index of the inferior vena cava parameters cannot fully reflect the blood volume, the sensitivity and specificity of predicting hypotension after induction are not very satisfied. Recent reports have demonstrated that respirophasic variation in carotid artery blood flow peak velocity (ΔVpeak) and carotid corrected flow time (FTc) can noninvasively assess patient responsiveness to fluids. Thus, we speculate that the combined measurement of the parameters of the carotid artery and the inferior vena cava may more comprehensively and accurately assess the patient's blood volume status, thereby accurately predicting the occurrence of hypotension after induction of anesthesia.
Hypotension is common after induction of general anesthesia, with an incidence of 9% to 90%. Hypotension after induction of anesthesia may increase the risk of cardiovascular and cerebrovascular accidents, postoperative cognitive dysfunction, as well as increase the risk of postoperative acute myocardial injury and increase the mortality rate during hospitalization. The aim of this study is to establish an assessment method that can effectively predict hypotension after induction of anesthesia, so as to prevent possible harm to patients from perioperative hypotension. The study is planned to measure the peak flow velocity variation and corrected blood flow time of the carotid artery, the diameter and cross-sectional area of the inferior vena cava by applying ultrasound before anesthesia, and record the blood pressure and heart rate before induction of anesthesia, and the blood pressure and heart rate per minute within 10 minutes after induction of tracheal intubation. The mean arterial pressure (MAP) was recorded as the basal value before induction of anesthesia. After induction of anesthesia, MAP \< 60 mmHg, or a decrease of more than 30% of the basal value, was defined as the occurrence of hypotension.
1,003 studies on the registry are indexed under Hypotension; 173 are open to participants now.
This study's planned enrollment of 106 is above the median of 84 across 294 observational studies indexed under Hypotension.
Browse Hypotension studies →Tongji Hospital is the lead sponsor of 373 studies on the registry; 204 are open to participants now.
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Conscious adult patients with normal intra-abdominal pressure; no patients with severe diabetes, no severe carotid stenosis and plaque
Exclusion Criteria:
Blood pressure assessment：The blood pressure and heart rate before induction and the blood pressure and heart rate per minute within 10 minutes after induction intubation were recorded. After induction of anesthesia, MAP \< 60 mmHg, or the decrease rate exceeded 30% of the baseline value, was defined as the occurrence of hypotension
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Time frame: Before induction of anesthesia
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Time frame: After induction of anesthesia to before tracheal intubation
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Time frame: after induction of anesthesia tracheal intubation 1 minute
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Time frame: after induction of anesthesia tracheal intubation 2 minute
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Time frame: after induction of anesthesia tracheal intubation 3 minute
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Time frame: after induction of anesthesia tracheal intubation 4 minute
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Time frame: after induction of anesthesia tracheal intubation 5 minutes
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Time frame: after induction of anesthesia tracheal intubation 6 minute
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Time frame: after induction of anesthesia tracheal intubation 7 minutes
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Time frame: after induction of anesthesia tracheal intubation 8 minutes
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Time frame: after induction of anesthesia tracheal intubation 9 minutes
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Predictive power of the post-induced hypotension of combined carotid artery sonography with inferior vena cava sonography
Time frame: after induction of anesthesia tracheal intubation 10 minutes
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Tongji Hospital