An observational study in ARDS, Human, PEEP, Occult and Esophageal and Pleural Pressure, sponsored by Peking Union Medical College Hospital. Completed at 1 site in China. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2022-07-01.
Sponsored by Peking Union Medical College Hospital · Observational
Esophageal manometry was used as surrogate of pleural pressure to titrate positive end-expiratory pressure (PEEP) in ARDS patients. However, Absolute values of esophageal pressure (Pes) could be affected by the PEEP setting. In moderate to severe ARDS patients, the end-expiratory Pes changed differently with PEEP adjustment. and the esophageal phenotypes could be divided into type I and type II. with Type I （ΔPes≥30%ΔPEEP）and Type II（ΔPes\<30%ΔPEEP）.
1,596 studies on the registry are indexed under Respiratory Distress Syndrome; 312 are open to participants now.
This study's enrollment of 18 is below the median of 100 across 540 observational studies indexed under Respiratory Distress Syndrome.
Browse Respiratory Distress Syndrome studies →Peking Union Medical College Hospital is the lead sponsor of 1,115 studies on the registry; 463 are open to participants now.
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Adult patients all the moderate to severe ARDS with P/F\<200 no contraindication to esophageal catheter
Exclusion Criteria:
Other: PEEP adjustment
Other: PEEP adjustment
adjusting PEEP about 3-5cmH2O (increase or decrease)
the changes of esophageal pressure during the PEEP titration
Time frame: March 1st to May 31st, 2022
Plan to share: No
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This study is completed, as verified in Jun 2022. You cannot join it, but the record below documents what was studied.
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Peking Union Medical College Hospital