An interventional study of Cardiac magnetic resonance imaging to study coronary microvascular dysfunction in Myocardial Infarction with Nonobstructive Coronary Arteries, sponsored by Karolinska Institutet. Recruiting at 1 site in Sweden. Open to participants aged 35 Years to 79 Years. Per ClinicalTrials.gov, last updated 2025-03-10.
Sponsored by Karolinska Institutet · Not applicable, Interventional, and Diagnostic
The present pilot study will investigate the prevalence of CMD in an unselected cohort of patients with the working diagnosis MINOCA and to study if the diagnostic yield can be improved by adding adenosine to the CMR investigation. Patient will be their own controls.
29 studies on the registry are indexed under MINOCA; 18 are open to participants now.
Browse MINOCA studies →Karolinska Institutet is the lead sponsor of 1,148 studies on the registry; 276 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
GFR (glomerular filtration rate) is how much blood the kidneys filter each minute. It is usually estimated from a blood test — eGFR, by formulas such as CKD-EPI or MDRD — and some studies ask for it to be measured directly instead. Usually given in mL/min/1.73 m².
Check the method, the units and the minimum the study states. A value of 90 or above is in the normal-or-high range, but kidney damage can show in other tests too.
GFR and eGFR (kidney filtering)
GFR (glomerular filtration rate) is how much blood the kidneys filter each minute. It is usually estimated from a blood test — eGFR, by formulas such as CKD-EPI or MDRD — and some studies ask for it to be measured directly instead. Usually given in mL/min/1.73 m².
Check the method, the units and the minimum the study states. A value of 90 or above is in the normal-or-high range, but kidney damage can show in other tests too.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients will be their own controls
Diagnostic Test: Cardiac magnetic resonance imaging to study coronary microvascular dysfunction
Myocardial perfusion mapping will be investigated after administration of adenosine
Diagnostic yield
To increase the diagnostic yield of CMR imaging in MINOCA as a working diagnosis
Time frame: Through investigation completion, usually 2 hours
Prevalence of CMD in MINOCA
To determine the proportion of patients with the working diagnosis of MINOCA who have CMD.
Time frame: Through investigation completion, usually 2 hours
Prevalence of CMD in different final MINOCA diagnoses
To study the proportions of CMD in patients with a CMR imaging diagnosis of myocardial infarction, Takotsubo, respectively myocarditis and compare them with the results from a healthy control group
Time frame: Through investigation completion, usually 2 hours
Angina pectoris
To investigate the occurrence of angina pectoris before inclusion and after 3 months and relate it to CMD
Time frame: 3 Months
Plan to share: No
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