An observational study in Movement Disorder, Tremor and Parkinson's Disease, sponsored by National Institute of Neurological Disorders and Stroke (NINDS). Recruiting at 1 site in United States. Open to participants aged 2 Years to 100 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-18.
Sponsored by National Institute of Neurological Disorders and Stroke (NINDS) · Observational
Background:
A movement disorder is a condition that causes a person s body to move in ways that are not normal. There are different types. Some disorders cause movements people can t control, such as tics or shaking. Some cause reduced or slow movements. Movement disorders can cause disability in people. Sometimes members of the same family will have the same disorder. Researchers want to learn more about how people develop these disorders. This research could lead to better treatments.
Objective:
This natural history study will collect data on people with different types of movement disorders. It will also collect data on their family members. The data will support further research.
Eligibility:
Children and adults aged 2 years and older who have a movement disorder. Family members of people with movement disorders are also needed.
Design:
Participants will undergo screening. They will have a physical exam. Researchers will look at their existing medical images. Any photographs or videos of their movements will also be reviewed.
Most participants will come to the NIH clinic for only 1 visit. They will answer questions about their condition. They will have normal tests used to diagnose their condition. They may have blood tests and different types of imaging scans. They may have tests to see how well their nerves function. The tests used will depend on the type of disorder they have.
Family members will have some of the same tests as people with disorders.
Participants will not receive any new treatments.
Some participants may be asked to return for a follow-up visit.
Up to 4000 people may participate.
Study Description:
This is a Natural History and Screening protocol for movement disorders, no research procedures will be done but the resulting data will be used for research.
Objectives:
Primary Objective: To collect data as part of standard of care evaluation of patients who have or are suspected to have a movement disorder and their family members for use in future secondary research.
Endpoints:
Collection of data from clinical/routine care that will contribute to/be used for future research.
371 studies on the registry are indexed under Movement Disorders; 102 are open to participants now.
This study's planned enrollment of 4,000 is above the median of 67 across 140 observational studies indexed under Movement Disorders.
Browse Movement Disorders studies →National Institute of Neurological Disorders and Stroke (NINDS) is the lead sponsor of 601 studies on the registry; 56 are open to participants now.
Of its 18 completed or terminated interventional studies of FDA-regulated products, 8 (44%) have results posted.
Counted across the registry records on this site, refreshed daily.
The following population groups may participate: - Subjects with neurological disorders who are 2 years old or older, - Family members who are 2 years old or older of people with a neurological disorder
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
In order to be eligible to participate in this study, an individual must meet all of the following criteria:
Either one of these:
EXCLUSION CRITERIA:
An individual who meets the following criteria will be excluded from participation in this study:
-Being \< 2 years old.
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
family members who are 2 years old or older of people with movement disorders
subjects with movement disorders who are 2 years old or older
to screen patients with movement disorders and family members of patients with movement disorders for enrollment in additional research protocols
The goal is to screen patients with movement disorders and family members of patients with movement disorders for enrollment in additional research protocols. No investigational treatments will be administered on this protocol and the NIH physicians will be playing a consultative role to the patient s primary physician.
Time frame: throughout protocol
Plan to share: Yes — All collected IPD stored in the database will be shared.
Supporting information: Study protocol
Time frame: Data will be shared no later than 1 year after the last patient visit and data will be shared for at least 2 years.
Access criteria: We do plan on broad data sharing. Therefore, there will be no restrictions on whom the de-identified data can be shared with.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
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National Institute of Neurological Disorders and Stroke (NINDS) →