An observational study in STEMI - ST Elevation Myocardial Infarction and Microvascular Coronary Artery Disease, sponsored by Lithuanian University of Health Sciences. Completed at 1 site in Lithuania. Open to participants aged 40 Years and older. Per ClinicalTrials.gov, last updated 2022-08-16.
Sponsored by Lithuanian University of Health Sciences · Observational
Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite of dietary choline, L-carnitine, and phosphatidylcholine-rich foods. On the basis of experimental studies and patients with prevalent disease, elevated plasma TMAO may increase risk of atherosclerotic cardiovascular disease (ASCVD). However, to our knowledge, no data is available on its impact on coronary microcirculation.
5,598 studies on the registry are indexed under Coronary Artery Disease; 957 are open to participants now.
This study's enrollment of 400 is above the median of 336 across 1,947 observational studies indexed under Coronary Artery Disease.
Browse Coronary Artery Disease studies →Lithuanian University of Health Sciences is the lead sponsor of 102 studies on the registry; 31 are open to participants now.
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This is a prospective, cohort study, conducted in the Hospital of the Lithuanian University of Health Sciences Kaunas Clinics.
Exclusion Criteria:
In brief, a 6-F angioplasty guiding catheter without side-holes will be used first used to engage the left main coronary artery. A pressure-temperature sensor guidewire ( PressureWire™ X Guidewire) will be used for physiology measurements including IMR measurements. Pressure measurement from the wire was first equalized with that of the guiding catheter. Then the pressure sensor will be positioned two-thirds of the way down the LAD artery. Intracoronary nitroglycerin will be administered (100 to 200 μg). Hyperemia will be induced with adenosine intracoronary injections.
Index of microcirculatory resistance
The index of microcirculatory resistance (IMR) will be detected using PressureWire™ X Guidewire
Time frame: 3 months
Left ventricular ejection fraction
left ventricular ejection fraction will be assessed via echocardiography imaging using Simpson's biplane method.
Time frame: 3 months
major adverse cardiovascular events (MACE)
. MACE was defined as follows: cardiovascular death, non-fatal myocardial infarction, target vessel revascularization, recurrent hospitalization due to decompensated heart failure, and stroke (ischemic or hemorrhagic).
Time frame: up to 1 year
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Aug 2022. You cannot join it, but the record below documents what was studied.
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Lithuanian University of Health Sciences