An observational study in Vascular And Immunologic Diseases and Healthy Volunteers, sponsored by National Heart, Lung, and Blood Institute (NHLBI). Recruiting at 1 site in United States. Open to participants aged 18 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-04.
Sponsored by National Heart, Lung, and Blood Institute (NHLBI) · Observational
Background:
Diseases involving blood, blood vessels, and immune systems are leading causes of death in the United States. Researchers studying these diseases need to compare blood samples from both healthy and sick individuals. Blood samples from healthy people are also used to establish what is normal when developing new tests for diseases and to make sure new testing equipment is working properly.
Objective:
This natural history study will collect blood samples from healthy people. The blood will be used for various kinds of research.
Eligibility:
Healthy adults aged 18 years or older. Pregnant or nursing women will be excluded.
Design:
Participants will have a telehealth visit or telephone call to review their medical history.
They will come to the NIH Clinical Center. They will have a needle inserted into a vein in their arm or hand. About 10 tablespoons of blood will be drawn through the needle.
Researchers may perform a complete blood count, a type of blood test that can help evaluate the participant s overall health. They may do a blood type test.
The blood samples will also be used for genetic studies.
Some blood samples may be stored for use in future research.
Participants may choose to return for repeat visits for up to 10 years. Review of their medical history may also be repeated at later visits. They will receive $50 per blood collection visit.
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Study Description:
This study will serve to provide tissue samples from individuals with healthy vasculature for mechanistic studies of vascular inflammation and thrombosis.
Objectives:
Primary Objective:
To collect samples from healthy volunteers to:
Endpoints:
This protocol does not have an outcome measure, but rather will be conducted in accordance with Good Clinical Practices for human research solely for the purpose of obtaining blood samples to optimize assays, conduct mechanistic investigations, measure vascular biomarkers, and facilitate the study of vascular and immunologic diseases in patients enrolled in other studies.
Healthy Volunteers
In order to be eligible to participate in this study, an individual must meet all of the following criteria:
EXCLUSION CRITERIA:
An individual who, by self-report, meets the following criteria will be excluded from participation in this study:
-Current pregnancy or lactation
Healthy Adults
To collect samples from healthy volunteers to establish and validate technical assays and normal physiologic mechanisms and parameters for on-going and future basic and translational research studies.
This protocol does not have an outcome measure, but will obtain blood samples to optimize assays, conduct mechanistic investigations, measure vascular biomarkers, and facilitate the study of vascular and immunologic diseases in patients enrolled in other studies.
Time frame: Up to 10 Years
Plan to share: No
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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National Heart, Lung, and Blood Institute (NHLBI)