CClinicalTrials.gg
CompletedNCT05401721Updated Jun 2, 2022

Serum Copeptin in Cirrhotic Patients With Spontaneous Bacterial Peritonitis

An observational study in Spontaneous Bacterial Peritonitis, sponsored by Sohag University. Completed at 1 site in Egypt. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2022-06-02.

Sponsored by Sohag University · Observational

Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
89
Ages
18 Years to 80 Years
Sex
All
01

Study summary

Current reports have demonstrated that copeptin predicts disease progression and prognosis in cirrhotic patients, independent of liver-specific scoring systems. To the best of our knowledge, few studies have addressed the association between copeptin and sepsis in cirrhotic patients, however, they were performed on different types of infections. Therefore, we will conduct this study with a focus on it is possible role in patients with SBP.

02

Conditions studied

  • Spontaneous Bacterial Peritonitis

Browse trials for

03

In context

Peritonitis

185 studies on the registry are indexed under Peritonitis; 25 are open to participants now.

This study's enrollment of 89 is below the median of 127 across 59 observational studies indexed under Peritonitis.

Browse Peritonitis studies →

Lead sponsor

Sohag University is the lead sponsor of 1,183 studies on the registry; 612 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with liver cirrhosis and ascites

Inclusion criteria

  • The diagnosis of liver cirrhosis will be based on clinical data and findings on abdominal ultrasound. The diagnosis of SBP will be based on the presence of at least 250 cells/ml PMNLs in the ascitic fluid, with or without positive ascitic fluid culture in the absence of hemorrhagic ascites and secondary peritonitis

Exclusion criteria

Exclusion Criteria:

  • Patients with heart failure, coronary insufficiency, advanced chronic respiratory disease, polyuria-polydipsia syndrome and hypotension or shock.

    • Patients with chronic kidney disease treated with hemodialysis before admission.
    • Patients with previous liver or kidney transplantation.
    • Patients with intraabdominal malignancy.
    • Patients with severe infection other than SBP.
    • Patients who had received antibiotics before hospital admission.
05

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
89 participants (actual)
Patient registry
No

Groups and cohorts

  • Ascites without SBP

    Cirrhotic ascitic patients not diagnosed with SBP

    Diagnostic Test: Serum copeptin

  • Ascites with SBP

    Cirrhotic ascitic patients diagnosed with SBP

    Diagnostic Test: Serum copeptin

Interventions

  • Diagnostic testSerum copeptin

    Blood test

06

What researchers measure

Primary outcomes

  1. compare serum levels of copeptin in cirrhotic patients with and without SBP

    compare serum levels of copeptin in cirrhotic patients with and without SBP

    Time frame: 6 months

Secondary outcomes

  1. assess serum copeptin levels in different stages of cirrhosis and its relationship with kidney and circulatory function

    assess serum copeptin levels in different stages of cirrhosis and its relationship with kidney and circulatory function

    Time frame: 6 months

07

Study locations

1 site
  • Sohag Faculty of Medicine
    Sohag, 82524, Egypt
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 2, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05401721
Lead sponsor
Sohag University
Responsible party
Ahmed Abudeif Abdelaal, MD (Principal investigator, Sohag University) — Principal investigator
First posted
Jun 2, 2022
Start date
May 1, 2021
Primary completion
Dec 1, 2021
Completion
Dec 1, 2021
Last update
Jun 2, 2022

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2022. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion