An interventional study of OneClick Social Engagement Intervention and OneClick Social Engagement Intervention Extension in Aging, Mild Cognitive Impairment and Aging Well, sponsored by University of Illinois at Urbana-Champaign. Completed at 2 sites in United States. Open to participants aged 65 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-19.
Sponsored by University of Illinois at Urbana-Champaign · Not applicable, Interventional, and Other
Among 1,418 studies in Cognitive Dysfunction with a site in United States — 328 open to participants now, 432 under way, 13 of them phase 3. Cognitive Dysfunction · United States.
Among the 1,418 studies in Cognitive Dysfunction with a site in United States, this one is the 377th largest by enrollment of the 1,143 interventional ones that give a count, is one of 107 that started in 2022, is one of 713 with no phase, and was the 970th registered.
3,872 studies on the registry are indexed under Cognitive Dysfunction; 1,119 are open to participants now.
This study's enrollment of 99 is above the median of 64 across 2,794 interventional studies indexed under Cognitive Dysfunction.
Browse Cognitive Dysfunction studies →328 of the 1,418 studies in Cognitive Dysfunction with a site in United States are open now, in 12 countries. Each count lists the studies.
Of the 750 Cognitive Dysfunction studies recruiting now, 362 (48%) set no upper age limit and 143 (19%) stop at 75 or younger; 46 take children under 18; 259 take healthy volunteers.
This study: 65 Years and older · all sexes · healthy volunteers too.
The full table on the hub →1,418 studies; the count open now beside each. This study's row is marked.
First in 1993; this study’s year is marked. 107 started in 2022.
Median enrollment 58 across the 1,143 interventional studies, 150 across the 270 observational. Of the 885 that completed or were terminated, 377 (43%) have results posted.
209 of 1,418 have an industry lead sponsor. The 10 most frequent:
University of Illinois at Urbana-Champaign is the lead sponsor of 191 studies on the registry; 29 are open to participants now.
University of Illinois at Urbana-Champaign has 8 studies filed under Cognitive Dysfunction — fewer than ten, so there is no comparison to draw.
180 of the studies in Cognitive Dysfunction with a site in United States that are under way reach primary completion within a year, 4 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT03860857Phase 3University of California, IrvineBiomarker Exploration in Aging, Cognition and Neurodegeneration | 2026-12-22 |
| NCT03887455Phase 3Eisai Inc.A Study to Confirm Safety and Efficacy of Lecanemab in Participants With Early Alzheimer's Disease | 2026-12-31 |
| NCT06191965Phase 3Mclean HospitalMitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction | 2027-01-31 |
| NCT06950190Phase 3Ellis MedicineEvaluating Cognitive Changes on Patients in Chemotherapy (ECCPC) | 2027-02-20 |
| NCT03560960Boston UniversityMulti-Center Development of a Novel Diagnostic Test for Alzheimer's Disease | 2026-11 |
Among the 1,418 studies in Cognitive Dysfunction with a site in United States, from their registry updates:
The goal of this randomized controlled trial is to rigorously assess the efficacy of an 8-week social engagement OneClick intervention. A total of 120 older adults with and without mild cognitive impairment (60 per group) will be randomized after a baseline assessment to the social engagement OneClick intervention group or the waitlist control group. Participants assigned to the intervention group will receive the social engagement OneClick intervention for 8 weeks, and will complete a mid-assessment at week 4, and a post-assessment at week 8. Participants assigned to the waitlist control group will receive no intervention for the first 8 weeks and will complete assessments at week 4 and week 8. Subsequently, as an extension to this study, participants assigned to the waitlist control group will have an opportunity to participate in 8 weeks of social engagement OneClick intervention.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
MMSE and MoCA
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Intervention group participants will receive the social engagement OneClick intervention for 8 weeks, and will complete a mid-assessment at week 4, and a post-assessment at week 8.
Other: OneClick Social Engagement Intervention
Waitlist control group participants will receive no intervention for the first 8 weeks and will complete assessments at week 4 and week 8. Following the completion of the 8-week controlled portion, waitlist participants will be provided with the opportunity to participate in the OneClick social engagement intervention through the intervention extension.
Other: OneClick Social Engagement Intervention Extension
Intervention group participants will receive the social engagement OneClick intervention for 8 weeks, and will complete a mid-assessment at week 4, and a post-assessment at week 8. Participants will use a computer or tablet to participate in two social engagement events per week. The intervention events will be delivered through the OneClick video conferencing platform. During each session participants will watch a short slideshow around a series of topics (e.g., nature, technology, hobbies) and get to engage in conversations surround the topics presented, which will be held in breakout rooms. Breakout room discussions will be set for 30 minutes, and participants will be provided with questions surrounding the topics to help stimulate conversation.
Waitlist control group participants will receive no intervention for the first 8 weeks and will complete assessments at week 4 and week 8. Following the completion of the 8-week controlled portion, waitlist participants will be provided with the opportunity to participate in the OneClick social engagement intervention through the intervention extension. Waitlist participants will use a computer or tablet to participate in two social engagement events per week. The intervention events will be delivered through the OneClick video conferencing platform over the span of 8 weeks.
Change in Social Isolation Measured by Friendship Scale
Measures six dimensions that contribute to social isolation. Lower scores indicate lower extent of social isolation. Range (0-24)
Time frame: Baseline, Week 4, Week 8
Change in Loneliness Measured by University of California - Los Angeles (UCLA) Loneliness Scale
Measures the respondents' subjective feeling of loneliness. Higher scores indicate a greater feeling of loneliness. Range (20-80).
Time frame: Baseline, Week 4, Week 8
Change in Quality of Life Measured by Quality of Life in Alzheimer's Disease
Measures quality of life indicators such as physical health, energy, family, and money. Lower scores indicate a lower quality of life. Range (13-52).
Time frame: Time Frame: Baseline, Week 4, Week 8
Change in Social Network Measured by Lubben Social Network Index
Measures social network size for both family and friends and also the frequency of interaction with them. Higher scores indicate higher level of social engagement. Range (0-30).
Time frame: Baseline, Week 4, Week 8
Change in Social Activity Measured by Social Activity Frequency
Measures how often during the past year participants have engaged in various social activities. Lower scores indicate less engagement in social activities. Range (10-50).
Time frame: Baseline, Week 4, and Week 8
Change in System Usability Measured by System Usability Scale
Measures the respondents' perception of usability of the OneClick system. Higher scores indicate higher ease of use and usefulness, and lower scores indicate more difficulty to use the system and decreased usefulness. Range (0-100).
Time frame: Week 4 of intervention, Week 8 of intervention
Change in Technology Acceptance Measured by Technology Acceptance Survey
Measure of technology acceptance: perceived ease of use. Lower scores indicate lower perception of ease of use. Range (1-7).
Time frame: Week 4 of intervention, Week 8 of intervention
Change in Computer Proficiency Measure by Computer Proficiency Questionnaire (Short -Form)
Measures the ability to perform a number of tasks using a computer. Tasks include computer basics, printing, communication, internet, scheduling, and multimedia. Higher scores indicated higher rates of proficiency. Range (6-30).
Time frame: Week 4 of intervention, Week 8 of intervention
| Milestone | OneClick Social Engagement Intervention Group | OneClick Social Engagement Waitlist Control Group |
|---|---|---|
| Started | 50 | 49 |
| Completed | 41 | 46 |
| Not completed | 9 | 3 |
Measures six dimensions that contribute to social isolation. Lower scores indicate lower extent of social isolation. Range (0-24)
| score on a scale | OneClick Social Engagement Intervention Group | OneClick Social Engagement Waitlist Control Group |
|---|---|---|
| Baseline | 20.37 ± 3.26 | 20.54 ± 3.30 |
| Week 4 | 20.05 ± 3.31 | 20.23 ± 3.35 |
| Week 8 | 20.39 ± 3.05 | 19.54 ± 4.34 |
Measures the respondents' subjective feeling of loneliness. Higher scores indicate a greater feeling of loneliness. Range (20-80).
| score on a scale | OneClick Social Engagement Intervention Group | OneClick Social Engagement Waitlist Control Group |
|---|---|---|
| Baseline | 37.93 ± 8.94 | 37.08 ± 9.35 |
| Week 4 | 40.34 ± 8.88 | 38.60 ± 9.35 |
| Week 8 | 38.05 ± 8.92 | 39.00 ± 9.62 |
Measures quality of life indicators such as physical health, energy, family, and money. Lower scores indicate a lower quality of life. Range (13-52).
| score on a scale | OneClick Social Engagement Intervention Group | OneClick Social Engagement Waitlist Control Group |
|---|---|---|
| Baseline | 37.52 ± 5.21 | 37.81 ± 5.11 |
| Week 4 | 36.88 ± 5.56 | 36.63 ± 5.52 |
| Week 8 | 37.44 ± 5.48 | 36.54 ± 5.57 |
Measures social network size for both family and friends and also the frequency of interaction with them. Higher scores indicate higher level of social engagement. Range (0-30).
| score on a scale | OneClick Social Engagement Intervention Group | OneClick Social Engagement Waitlist Control Group |
|---|---|---|
| Baseline | 18.75 ± 4.43 | 19.08 ± 4.55 |
| Week 4 | 17.59 ± 5.50 | 17.28 ± 4.90 |
| Week 8 | 17.51 ± 4.50 | 17.54 ± 4.74 |
Measures how often during the past year participants have engaged in various social activities. Lower scores indicate less engagement in social activities. Range (10-50).
| score on a scale | OneClick Social Engagement Intervention Group | OneClick Social Engagement Waitlist Control Group |
|---|---|---|
| Baseline | 26.84 ± 4.01 | 27.98 ± 3.98 |
| Week 4 | 27.63 ± 4.08 | 27.89 ± 5.05 |
| Week 8 | 28.07 ± 4.69 | 27.30 ± 4.44 |
Measures the respondents' perception of usability of the OneClick system. Higher scores indicate higher ease of use and usefulness, and lower scores indicate more difficulty to use the system and decreased usefulness. Range (0-100).
| Raw Score | OneClick Social Engagement Intervention Group |
|---|---|
| Change Score at Week 4 | 63.80 ± 18.7 |
| Change Score at Week 8 | 68.20 ± 18.6 |
Measure of technology acceptance: perceived ease of use. Lower scores indicate lower perception of ease of use. Range (1-7).
| score on a scale | OneClick Social Engagement Intervention Group |
|---|---|
| Change Score at Week 4 | 5.40 ± 1.4 |
| Change Score at Week 8 | 5.70 ± 1.2 |
Measures the ability to perform a number of tasks using a computer. Tasks include computer basics, printing, communication, internet, scheduling, and multimedia. Higher scores indicated higher rates of proficiency. Range (6-30).
| score on a scale | OneClick Social Engagement Intervention Group |
|---|---|
| Change Score at Week 4 | 27.60 ± 2.8 |
| Change Score at Week 8 | 28.10 ± 2.6 |
Collected over up to 16 weeks. Non-serious events are listed at a 0% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| OneClick Social Engagement Intervention Group | 0/50 (0%) | 0/50 (0%) | 0/50 (0%) |
| OneClick Social Engagement Waitlist Control Group | 0/49 (0%) | 0/49 (0%) | 0/49 (0%) |
| Age, Continuous(years) | OneClick Social Engagement Intervention Group | OneClick Social Engagement Waitlist Control Group | Total |
|---|---|---|---|
| Mean | 73.5 ± 6.3 | 74.6 ± 7.1 | 74.05 ± 6.7 |
| Sex: Female, Male(Participants) | OneClick Social Engagement Intervention Group | OneClick Social Engagement Waitlist Control Group | Total |
|---|---|---|---|
| Female | 38 | 43 | 81 |
| Male | 12 | 6 | 18 |
| Race (NIH/OMB)(Participants) | OneClick Social Engagement Intervention Group | OneClick Social Engagement Waitlist Control Group | Total |
|---|---|---|---|
| American Indian or Alaska Native | 0 | 0 | 0 |
| Asian | 0 | 0 | 0 |
| Native Hawaiian or Other Pacific Islander | 0 | 0 | 0 |
| Black or African American | 2 | 5 | 7 |
| White | 46 | 40 | 86 |
| More than one race | 1 | 4 | 5 |
| Unknown or Not Reported | 1 | 0 | 1 |
| Region of Enrollment(participants) | OneClick Social Engagement Intervention Group | OneClick Social Engagement Waitlist Control Group | Total |
|---|---|---|---|
| United States | 50 | 49 | 99 |
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: No
Ran from Apr 2022 to primary completion in Apr 2023, 11 months.
Results were first posted in Jan 2026, 2 years 9 months after primary completion.
Of 1,442 non-industry interventional studies with no phase under Cognitive Dysfunction, half reached primary completion within 27 months of starting (the median), counting those still running; a quarter within 13 and three quarters within 51. This study's 11 months is below that.
Counting every sponsor, half of 1,511 studies reached it within 27 months; a quarter within 12 and three quarters within 50.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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University of Illinois at Urbana-Champaign →