An observational study in Varicocele, sponsored by Assiut University. Status unknown. Open to male participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2022-04-15.
Sponsored by Assiut University · Observational
Evaluate the effect of recent ejaculation on scrotal duplex parameters in infertile males with varicocele
Varicocele is abnormal dilatation of the pampiniform plexus veins draining the testicles.
It manifests as an abnormal retrograde flow in the internal spermatic venous system or dilation of venous branches in the external cremasteric system .
It affects approximately 15% in the general population, 35 - 40% in men with primary infertility and approximately 80% of men with secondary infertility. It could often concomitantly occur with infertility or chronic scrotal pain causing impaired spermatogenesis and is the most common correctable cause of male infertility. it may affects spermatogenesis via different mechanisms such as increased testicular heat, hormonal disorders and reflux of toxic metabolites.
Scrotal colour Doppler ultrasonography (USG) is a widely used method for evaluation of varicocele patients . It can be used along with physical examination in these patients through evaluation of vein reflux and diameter; in cases where palpation may be problematic. Furthermore, the degree of reflux and vein diameter can be used during the decision-making stage while treating varicocele .
Ejaculation is the process by which sperms move from epididymis via vas deferens to urethra and finally expelled out through the urethral meatus by the contraction of smooth muscles. A normal antegrade ejaculation consists of emission, expulsion (ejection), and orgasm .
In the evaluation of infertile patients, semen analysis is required for evaluation of number, motility and morphology of spermatozoa with scrotal colour Doppler USG. Ejaculation for the purpose of sperm analysis is known to significantly increase testicular blood supply .
57 studies on the registry are indexed under Varicocele; 16 are open to participants now.
This study's planned enrollment of 200 is above the median of 119 across 17 observational studies indexed under Varicocele.
Browse Varicocele studies →Assiut University is the lead sponsor of 5,050 studies on the registry; 2,174 are open to participants now.
Of its 14 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Infertile male patients with scrotal varicocele aging over 18 years old.
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Exclusion Criteria:
Scrotal colour doppler ultrasonography
Assessment of varicose vein diameter pre and post ejaculation.
Assessment of the change in varicose vein diameter by scrotal colour doppler ultrasonography pre ejaculation and within 30 minutes post ejaculation.
Time frame: within 30 minutes post ejaculation
Assessment of varicose vein reflux time pre and post ejaculation.
Assessment of varicose vein reflux time by scrotal duplex pre ejaculation and within 30 minutes post ejaculation.
Time frame: Within 30 minutes post ejaculation
No study locations are listed for this record.
Start is estimated for Nov 2022; primary completion for Nov 2023, 12 months later.
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This study is status unknown, as verified in Mar 2022. You cannot join it, but the record below documents what was studied.
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