An observational study in Heart Failure, Diastolic, sponsored by German Heart Institute. Completed at 1 site in Germany. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-04-11.
Sponsored by German Heart Institute · Observational
The diagnosis of heart failure with preserved ejection fraction has so far been made primarily according to criteria determined by echocardiography, or invasively by measuring the left ventricular filling pressures. Increasingly, CMR is also evaluated with regard to the diagnosis of cardiac insufficiency with preserved pump function.However, it is still unclear which parameters can be used meaningfully for diagnostics.To answer this question, the investigators want to retrospectively evaluate data collected from patients with a clinical indication for CMR and coronary angiography.
Heart failure with preserved pump function is a common disease that is associated with a high level of suffering for the patient. The diagnosis has so far been made primarily according to criteria determined by echocardiography, or invasively by measuring the left ventricular filling pressures.
With its high spatial resolution and the possibility of tissue-specific diagnostics, cardiac MRI (CMR) offers outstanding possibilities in cardiac imaging without exposing the patient to ionizing radiation. Increasingly, CMR is also evaluated with regard to the diagnosis of cardiac insufficiency with preserved pump function. However, it is still unclear which parameters can be used meaningfully for diagnostics. There is evidence for a correlation with invasively increased LVEDP, although the number of patients examined in the previous studies was still small. In addition, possible influences from medication and clinical parameters were not examined.
To answer this question, the investigators want to retrospectively evaluate data collected from patients with a clinical indication. The significance of the study is that in the future CMR could supplement echocardiography in the diagnosis of HFpEF and further reduce the need for invasive diagnostics.
5,701 studies on the registry are indexed under Heart Failure; 1,220 are open to participants now.
This study's enrollment of 190 is close to the median of 200 across 1,679 observational studies indexed under Heart Failure.
Browse Heart Failure studies →German Heart Institute is the lead sponsor of 25 studies on the registry; 7 are open to participants now.
Counted across the registry records on this site, refreshed daily.
atients with CMR and left heart catheterization including LVEDP measurement within the same month
Exclusion Criteria:
Clinically indicated cardiac magnetic resonance tomography executed according to international guideline recommendations.
Also known as: Cardiac magnetic resonance tomography
Extracellular myocardial volume (%)
Estimated percentage of extracellular volume of the myocardium
Time frame: One montth
Left atrial volume (ml)
Volume of the left atrium in mililiters
Time frame: One month
Plan to share: Undecided — Upon reasonable request anonymized IPD may be sharedn at the discretion of the PI.
No publications or documents are linked to this record.
This study is completed, as verified in Apr 2022. You cannot join it, but the record below documents what was studied.
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German Heart Institute