An observational study in Chronic Disease, Cancer and Dementia Alzheimers, sponsored by Guangzhou University of Traditional Chinese Medicine. Recruiting at 1 site in China. Open to participants aged 35 Years to 79 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-11-15.
Sponsored by Guangzhou University of Traditional Chinese Medicine · Observational
The researchers plain to build a large-scale, longitudinal, prospective cohort characterized by TCM dampness syndrome. With the biobank of this cohort the investigators want to find the causality between TCM dampness syndrome and clinical chronic diseases and a new way to treat clinical disease.
DACOS is a national large- scale, longitudinal, multi-center, prospective, cohort study of natural person aged 35 to 75. The baseline survey and the follow-up surveys will be conducted in 5 areas covering the eastern, northern, western, southern and middle parts of China. In this study 100,000 natural person will be regularly followed up for 5 years(visited once a year), with the loss rate ≤15%. Three parts will be carried in the form of interview, physical examination and biological sample collection. During the interview, the investigators plan to do some questionnaires to learn participants' demographic characteristics, life style, disease history, healthy condition(EQ-5D-5L, SDS,), cognition state(AD-8, MMSE, MoCA) and the results of TCM syndrome differentiation(Score of Dampness syndrome and TCM constitution scale). All biological specimens (including blood, feces, urine, saliva and tongue coating) will be collected and stored in the biological resource center until researchers request their use. With the building up of this cohort, the researchers will analyze the causality between dampness syndrome and specific chronic diseases such as diabetes, coronary heart disease, cancer, dementia and so on.
3,681 studies on the registry are indexed under Alzheimer Disease; 875 are open to participants now.
This study's planned enrollment of 100,000 is above the median of 200 across 753 observational studies indexed under Alzheimer Disease.
Browse Alzheimer Disease studies →Guangzhou University of Traditional Chinese Medicine is the lead sponsor of 57 studies on the registry; 19 are open to participants now.
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general population in a specific area and specifc time range. Such as civil servants of Guangdong Province. Medical workers in Xinjiang.
Exclusion Criteria:
general population in a specific area and specifc time range.
Other: natural aging process
To observe the relationship between new cases of diseases and health status of people exposed to different factors such as life style, alcohol consumption, eating habits, etc.
emerging diseases
This study will pay attention to the emerging situation of clinical chronic diseases, such as cancer, diabetes, hypertension, coronary heart disease, dementia, etc. Each follow-up the researchers will record the incidence of the emerging diseases of interviewees' by questionnaire including the name of the disease, time of onset and treatments.
Time frame: through study completion, an average of 1 year
Montreal Cognitive Assessment(MoCA)
MoCA is a brief, 30-question test that helps healthcare professionals detect cognitive impairments very early on, allowing for faster diagnosis and patient care. MoCA is the most sensitive test available for detecting Alzheimer's disease, measuring executive functions and multiple cognitive domains. The value range 0-30: higher scores mean a better Cognitine. The score above 26 is considered the normal congnitive level
Time frame: through study completion, an average of 1 year
European Quality of Life 5-dimensional questionnaire (EQ-5D-5L)
The EQ-5D comprises five dimensions of health: mobility, ability to self-care, ability to undertake usual activities, pain and discomfort, and anxiety and depression. . EQ-5D-5L, includes five levels of severity for each dimension (no problems, slight problems, moderate problems, severe problems, and extreme problems). The value range 0-100: higher scores mean a worse outcome.
Time frame: through study completion, an average of 1 year
Mini-Mental State Exam (MMSE)
MMSE is a widely used test of cognitive function among the elderly; it includes tests of orientation, attention, memory, language and visual-spatial skills. The value range 0-30: higher scores mean a better Cognitine.
Time frame: through study completion, an average of 1 year
interview questionnaire
Demographic characteristic, life style. disease history, allergies will be involoved.
Time frame: through study completion, an average of 1 year
change of the blood routine results
WBC, RBC, PLT , HB, NEUT% and LYM% will be tested and recorded. Above or below each mormal value will be considered as abnormal.
Time frame: through study completion, an average of 1 year
urine routine
urinary WBC and urinary RBC will be observed. negative or below 5/HP is normal. BLO and GLU and PRO in urine will also be test. Negative is normal.
Time frame: through study completion, an average of 1 year
change of faeces routine
cells in faeces will be tested such as RBC and WBC. Negative occult blood（FOB) is difined normal.
Time frame: through study completion, an average of 1 year
change of hepatic function
The researchers will check the results of ALT and AST. TBil, DBIL, TBA and TP, ALB. Any indices above or below the criteria range is defined as abnormal. Every time point investigators will record the change of these indices.
Time frame: an average of 1 year
change of renal function
The researchers will check the results of Cr， BUN, TC， LDL， HDL,UA and fasting blood glucose，glycosylanted. Any indices above or below the criteria range is defined as abnormal. Every time point investigators will record the change of these indices.
Time frame: an average of 1 year
change of CRP
change of CPP
Time frame: an average of 1 year
change of Hcy
change of Hcy
Time frame: an average of 1 year
change of thyroid function
change of TSH ,FT3, FT4
Time frame: an average of 1 year
change of Vit B12 and folic acid
change of Vit B12
Time frame: an average of 1 year
change of coagulation function
change of PT, INR,TT,APTT，FIB
Time frame: an average of 1 year
change of abdominal ultrasound
change of abdominal ultrasound
Time frame: an average of 1 year
change of gynecologic ultrasound
change of gynecologic ultrasound
Time frame: an average of 1 year
change of ECG
The researchers will check the change of P, QRS and ST segments separately in electrocardiogram.
Time frame: an average of 1 year
change of brain MRI
change of brain MRI. The investigators will focus on the change of hippocampal volume and the spacing of temporal sulcus gyrus.
Time frame: an average of 1 year
Plan to share: Yes — If you need to access or use the population information database and biological sample database, you must go through strict application and approval processes at first
Supporting information: Study protocol, Sap, Icf, Csr, Analytic code
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Guangzhou University of Traditional Chinese Medicine