An observational study in Myocardial Infarction, Coronary Microvascular Dysfunction and Vasospasm, Coronary, sponsored by Chonnam National University Hospital. Recruiting at 1 site in South Korea. Open to participants aged 19 Years and older. Per ClinicalTrials.gov, last updated 2026-05-12.
Sponsored by Chonnam National University Hospital · Observational
To compare clinical outcomes of myocardial infarction with non-obstructive coronary arteries (MINOCA) according to the coronary microvascular dysfunction (CMD), evaluated by optical coherence tomography (OCT), invasive and non-invasive coronary physiologic assessment.
Background Approximately 5\~10% of patients with acute myocardial infarction (AMI) have been reported as myocardial infarction with non-obstructive coronary arteries (MINOCA) in the contemporary clinical setting. Although those with MINOCA have a better prognosis than with obstructive coronary artery disease, several observational studies continuously reported that patients with MINOCA showed comparable outcomes. One plausible explanation of this discrepancy is the heterogeneous and variable definition of MINOCA. Possible causes of MINOCA include plaque erosion and/or rupture, vasospasm, and CMD. Therefore, it is natural that heterogeneous pathophysiology of MINOCA causes diagnostic challenges and proper management.
Recently, there have been efforts for establishing the diagnosis of MINOCA and standardizing the systematic management according to the cause of MINOCA. According to the AHA scientific statement, patients who suspected MINOCA have been recommended to perform multimodality approach, including intravascular imaging (i.e., OCT). Although non-invasive methods, such as N-13 ammonia positron emission tomography (PET), can be used for evaluating the CMD, invasive coronary physiologic assessment using pressure-temperature wire has been recommended. CMD has been known as a major cause of MINOCA, and it may be required specific treatment.
Nevertheless, there has no data on the outcomes of MINOCA with or without CMD. Therefore, the aim of CMD-MINOCA sought to assess the MINOCA patients regarding the latest clinical pathway for diagnosis of CMD and evaluate their clinical outcomes at 2 years.
29 studies on the registry are indexed under MINOCA; 18 are open to participants now.
This study's planned enrollment of 150 is below the median of 500 across 20 observational studies indexed under MINOCA.
Browse MINOCA studies →Chonnam National University Hospital is the lead sponsor of 72 studies on the registry; 15 are open to participants now.
Compared within MINOCA, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Myocardial Infarction. The counts are of registry records indexed under each term, refreshed daily. How we classify →
About 150 patients with suspected myocardial infarction underwent invasive coronary angiography, but without obstructive coronary arteries will be enrolled. These patients will be evaluated by OCT, coronary functional assessment including coronary spasm test, invasive (FFR, CFR, IMR) and non-invasive coronary physiologic assessment (N-13 ammonia positron emission tomography).
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Subject with age ≥19 years and acute myocardial infarction
Rise and/or fall of cardiac troponin with one level >99 percentile plus ischemic signs/symptoms
fractional flow reserve (FFR) >0.80 ③ Subject without previous history of coronary artery disease
Exclusion Criteria:
Subject with obstructive coronary arteries
Subject with alternate diagnosis including sepsis, pulmonary embolism, myocarditis, Takotsubo syndrome, spontaneous coronary dissection, and other cardiomyopathies.
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The study doctor’s estimate of how long someone is likely to live. Criteria use it so that people can stay in the study long enough for it to answer its question.
Life expectancy
The study doctor’s estimate of how long someone is likely to live. Criteria use it so that people can stay in the study long enough for it to answer its question.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
MINOCA patients with CMD proven by invasive or non-invasive method
Diagnostic Test: Intravascular imaging (OCT), Invasive physiologic assessment (FFR, CFR, IMR), or Non-invasive physiologic assessment (N-13 ammonia PET)
MINOCA patients without CMD
Diagnostic Test: Intravascular imaging (OCT), Invasive physiologic assessment (FFR, CFR, IMR), or Non-invasive physiologic assessment (N-13 ammonia PET)
Intravascular imaging (OCT), Invasive physiologic assessment (FFR, CFR, IMR), or Non-invasive physiologic assessment (N-13 ammonia PET)
MACCE
a composite of cardiac death, any MI, any revascularization, stroke, readmission due to heart failure
Time frame: 2-Year after enrollment
cardiac death
death from cardiac-cause
Time frame: 2-Year after enrollment
all-cause death
death from any-cause
Time frame: 2-Year after enrollment
Rate of myocardial infarction
any type of myocardial infarction
Time frame: 2-Year after enrollment
Rate of repeat revascularization
ischemia-driven or all
Time frame: 2-Year after enrollment
Rate of stroke
ischemic or hemorrhagic stroke by brain imaging
Time frame: 2-Year after enrollment
re-admission due to heart failure
re-admission due to heart failure
Time frame: 2-Year after enrollment
all-cause death, any MI, or any revascularization
a composite of all-cause death, any myocardial infarction, or any revascularization
Time frame: 2-Year after enrollment
Changes of left ventricular ejection fraction
left ventricular ejection fraction by echocardiography
Time frame: 2-Year after enrollment
Changes of Coronary flow reserve
Coronary flow reserve by PET
Time frame: 6-Month after enrollment
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: Yes — After the publication of the main paper, we have a plan to share IPD regarding the request.
Supporting information: Study protocol, Statistical analysis plan, Informed consent form, Clinical study report
Time frame: December 31, 2026 \~
Access criteria: Not specified. To be discussed.
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Chonnam National University Hospital