An interventional study of bolus/intermittant feeding in Enteral Feeding Intolerance, sponsored by Zekai Tahir Burak Women's Health Research and Education Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 1 Day to 3 Days. Per ClinicalTrials.gov, last updated 2026-03-19.
Sponsored by Zekai Tahir Burak Women's Health Research and Education Hospital · Not applicable, Interventional, and Other
achievement of optimal postnatal growth by adequate enteral nutrition in critically ill preterm infants is a challenge of NICU. signs like abdominal distension, reflux, vomiting, nec is a factors of discontinuing fedding in preterm. this factors plays a role in decisions about which method of gavage feeding is adopted. we compare two different feeding method to achive less fedding tolerence.
\<1750 gr, \<33 gw infants will enroll study. exckusion criteria: major congenital anomalies major gis anomalies
The study infants are enrolled within 24 hours of birth and sequently randomized to either intermitten feeding (IF) and bolus feeding (BF). Intermittent feeding is defined as delivering enteral nutrition and generally giving 60 min and 2 hours no feeding. this circle repeats 8 times in 24 hours. Bolus feeding is the amount of nutrition put into the syringe was kept 10 cm above the baby and the fluidity was obtained by gravity through the orogastric tube. The data of the patients such as feeding intolerance (gastric residual volume more than %50 of the previous feeding volume, gastric regurgitation, abdominal distension and/or emesis ), whether there is a week-by-week feeding intolerance were noted, NEC, time to reached birth weight, time to achieved full enteral feeding, every 5 minutes during feeding, saturation, respiratory rate and heart rates will record.
2,550 studies on the registry are indexed under Premature Birth; 500 are open to participants now.
This study's enrollment of 100 is above the median of 84 across 1,666 interventional studies indexed under Premature Birth.
Browse Premature Birth studies →Zekai Tahir Burak Women's Health Research and Education Hospital is the lead sponsor of 62 studies on the registry; 1 is open to participants now.
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Exclusion Criteria:
major congenital anomalies gis anomalies septic shock exitus in 3 days of life
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In bolus feednig group preterm fed by via gravity drip over a short period, usually 15-20 min. it administrated 8-12 times daily
Other: bolus/intermittant feeding
Intermittant feeding is delivered over a 30-60 min by infusion pump. it administrated 8-12 times daily
Other: bolus/intermittant feeding
sequential randomization
rate of feeding intolerence
The effect of two different gavage tube feeding methods on feeding intolerance
Time frame: 1 month
time to reach full enteral feeding
The effect of two different gavage tube feeding methods on time to reach full enteral feeding
Time frame: 1 month
Ran from Jan 2015 to primary completion in Jun 2022, 89 months.
Of 741 non-industry interventional studies with no phase under Premature Birth, half reached primary completion within 24 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 47. This study's 89 months is above that.
Counting every sponsor, half of 759 studies reached it within 24 months; a quarter within 12 and three quarters within 47.
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This study is completed, as verified in Feb 2022. You cannot join it, but the record below documents what was studied.
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Zekai Tahir Burak Women's Health Research and Education Hospital