A Phase 4 interventional study of Cymbopogon citratus (lemongrass) oil gel in Periodontitis Chronic Generalized Moderate, sponsored by Souzy Kamal. Completed at 1 site in Egypt. Open to participants aged 25 Years to 45 Years. Per ClinicalTrials.gov, last updated 2022-02-15.
Sponsored by Souzy Kamal · Phase 4, Interventional, and Treatment
Background: Phytotherapeutics is widely used nowadays as an adjunct to scaling and root planing (SRP) to modulate inflammatory host response and eradicate microbes. Matrix metalloproteinase-8 (MMP-8) is associated with the onset of inflammation and considered an indicative biomarker to the severity of inflammatory response. Since MMP-8 can be used as a predictive biomarker for treatment response; our research aimed to investigate clinically the effectiveness of intra-pocket application of Cymbopogon citratus (lemongrass oil) gel and biochemically on MMP-8 levels in gingival crevicular fluid (GCF) of stage II periodontitis patients.
Methods: A randomized controlled clinical trial was conducted on forty patients with stage II periodontitis, divided equally into two groups. Group-I (test) was managed by SRP with intra-pocket application of 2% lemongrass oil gel. Group-II (control) was managed by SRP with intra-pocket application of a placebo gel. Periodontal pocket depth (PPD) and clinical attachment loss (CAL) were measured for both groups, before treatment and twelve weeks after. Moreover, GCF was collected from both groups at baseline, one week, and twelve weeks after treatment. Then analysed by Enzyme-linked Assay (ELISA) technique.
1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.
This study's enrollment of 40 is below the median of 45 across 1,191 interventional studies indexed under Periodontitis.
Browse Periodontitis studies →This is the only study on the registry with Souzy Kamal as lead sponsor.
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Exclusion Criteria:
included twenty patients treated with SRP and intrapocket application of 2% lemongrass oil gel.
Drug: Cymbopogon citratus (lemongrass) oil gel
included twenty treated with SRP and intrapocket application of placebo gel.
Drug: Cymbopogon citratus (lemongrass) oil gel
Biochemical Efficacy of Cymbopogon Citratus Gel as Local Drug Delivery Agent in Reducing Matrix Metalloproteinase-8 Levels Intra-crevicularly in the Treatment of Stage II Periodontitis
Change in periodontal pocket depth
the distance between the gingival margin and depth of probing
Time frame: baseline and after 12 weeks
Change in clinical attachment loss
the distance between the CEJ and depth of probing
Time frame: baseline and after 12 weeks
Change in Matrix metalloproteinase-8 level
Human Matrix metalloproteinase-8 level intracrevicularlly by collection of crevicular fluid sample
Time frame: baseline and after 12 weeks
Plan to share: Yes — all IPD that underlie results in a publication
Supporting information: Study protocol, Icf
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This study is completed, as verified in Feb 2022. You cannot join it, but the record below documents what was studied.
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