An interventional study of Continous infusion and Single infusion in Tranexamic Acid, Intraoperative Blood Loss and Meningioma, sponsored by Beijing Tiantan Hospital. Recruiting at 1 site in China. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2022-08-29.
Sponsored by Beijing Tiantan Hospital · Not applicable, Interventional, and Prevention
Intra-operative blood loss of huge meningioma resection patients on average was over 1000ml. Intra-operative massive hemorrhage was associated with longer hospital of stay, higher expense, and higher mortality. Previous studies indicated intra-operative tranexamic acid infusion would decrease blood loss for cardiac, trauma and obstetric procedures. However, limited researches focusing on the effect of tranexamic acid in neurosurgery population, with heterogenous pathologies. The purpose of this study was to investigate the effect of tranexamic acid on intra-operative blood loss in patients undergoing huge meningioma resection.
226 studies on the registry are indexed under Meningioma; 87 are open to participants now.
This study's planned enrollment of 228 is above the median of 40 across 161 interventional studies indexed under Meningioma.
Browse Meningioma studies →Beijing Tiantan Hospital is the lead sponsor of 465 studies on the registry; 282 are open to participants now.
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Exclusion Criteria:
Infusion with 20mg/kg tranexamic acid and 5mg/kg/h tranexamic acid.
Drug: Continous infusion
Infusion with 20mg/kg tranexamic acid and same volume 0.9% saline.
Drug: Single infusion
Infusion with same volume of 0.9% saline.
Drug: Placebo
The 20mg/kg tranexamic acid will be diluted into a 50ml syringe and infused followed by 5mg/kg/h tranexamic acid infusion.
The 20mg/kg tranexamic acid will be diluted into a 50ml syringe and infused followed by same volume of 0.9% saline.
The 0.9% saline is administered with the same volume at the same speed as the other group.
Estimated intra-operative blood loss
Estimated intra-operative blood loss is assessed as following formula:collected blood volume in the suction canister (mL) - the volume of flushing (mL) + the volume from gauze tampon (mL).
Time frame: During surgery
Plan to share: Undecided
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Beijing Tiantan Hospital