An observational study in Neovascular Age-related Macular Degeneration, sponsored by The S.N. Fyodorov Eye Microsurgery State Institution. Completed at 1 site in Russian Federation. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-04-13.
Sponsored by The S.N. Fyodorov Eye Microsurgery State Institution · Observational
The study involves the development of an algorithm for predicting anatomical and functional results of therapy with angiogenesis inhibitors in patients with retinal pigment epithelium detachments in neovascular age-related macular degeneration, based on primary optical coherence tomography of the macular zone and clinical data.
Patients were divided into 3 groups according to the results of therapy: adhesion of detachment, lack of adherence to detachment, rupture of detachment. For these groups, OCT images of the macular zone with maximum detachment before therapy are selected. These images, along with other clinical parameters, are input to the algorithm. The result is one of the 3 treatment outcomes listed above. The methods that will be used to develop the algorithm include methods for processing and transforming data, deep machine learning, metrics for calculating the accuracy of algorithms.
1,474 studies on the registry are indexed under Macular Degeneration; 206 are open to participants now.
This study's enrollment of 300 is above the median of 106 across 421 observational studies indexed under Macular Degeneration.
Browse Macular Degeneration studies →The S.N. Fyodorov Eye Microsurgery State Institution is the lead sponsor of 11 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with retinal pigment epithelium detachments with age-related neovascular macular degeneration
Exclusion criteria:
the group in which the adhesion of neuroepithelial detachment was observed after Anti-vascular endothelial growth factor therapy
Procedure: Anti-vascular endothelial growth factor therapy
group in which there was no adherence of neuroepithelial detachment after Anti-vascular endothelial growth factor therapy
Procedure: Anti-vascular endothelial growth factor therapy
group in which neuroepithelial detachment rupture was observed after anti-vascular endothelial growth factor therapy
Procedure: Anti-vascular endothelial growth factor therapy
0.05 ml anti-VEGF, intravitreal, monthly
Also known as: anti-VEGF
Prediction algorithm
Neural network classifier
Time frame: 1.09.2022
This study is completed, as verified in Apr 2023. You cannot join it, but the record below documents what was studied.
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The S.N. Fyodorov Eye Microsurgery State Institution