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Status unknownNCT05204433Updated Jan 24, 2022

Correlation Between SFRP1 and Colorectal Cancer and Adenoma

An observational study in Early Diagnosis of Colorectal Cancer and Adenoma, sponsored by Xijing Hospital of Digestive Diseases. Status unknown at 1 site in China. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-01-24.

Sponsored by Xijing Hospital of Digestive Diseases · Observational

The sponsor has not verified this record recently (last verified Jan 2022), so the status shown — last known as Enrolling by invitation — may be out of date.
Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
220
Ages
18 Years to 80 Years
Sex
All
01

Study summary

In summary, our study demonstrated the methylation sites of SFRP1 gene promoter in patients with colorectal cancer and adenoma and found SFRP1_16_17_18 CpG site was good performance as a diagnostic marker of colorectal cancer.

02

Conditions studied

  • Early Diagnosis of Colorectal Cancer and Adenoma

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03

In context

Adenoma

661 studies on the registry are indexed under Adenoma; 101 are open to participants now.

This study's planned enrollment of 220 is below the median of 300 across 230 observational studies indexed under Adenoma.

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Lead sponsor

Xijing Hospital of Digestive Diseases is the lead sponsor of 81 studies on the registry; 22 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

consecutive adult patients undergoing an outpatient endoscopy

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • consecutive adult patients undergoing an outpatient endoscopy and histopathologically diagnosed as colorectal cancer or adenoma. Also, healthy individuals were invited to be enrolled.

Exclusion criteria

Exclusion Criteria:

  • Lynch syndrome
  • Familial adenomatous polyposis
  • MUTYH associated polyposis
  • Peutz-Jeghers syndrome
  • Juvenile polyposis syndrome
  • Serrated polyposis syndrome
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
220 participants (estimated)
Patient registry
No

Groups and cohorts

  • normal control

    healthy volunteers

    Other: no intervention

  • adenoma

    pathologically reported colorectal adenoma

    Other: no intervention

  • colorectcal cancer

    pathologically reported colon cancers

    Other: no intervention

  • High risk group

    pathologically reported inflammatory bowel diseases

Interventions

  • Otherno intervention

    no intervention

06

What researchers measure

Primary outcomes

  1. effectiveness of methylation markers from stool samples

    assess the effectiveness of methylation markers from stool samples in colon cancer patients, colorectal adenoma patients, compared with normal volunteers

    Time frame: 3 years

Secondary outcomes

  1. assess the capacities of RF model in screening potential clinical biomarkers.

    Time frame: 3 years

07

Study locations

1 site
  • Jie Liang
    Xi'an, Shaanxi 710012, China
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 24, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05204433
Lead sponsor
Xijing Hospital of Digestive Diseases
Responsible party
Jie Liang (Professor, Xijing Hospital of Digestive Diseases) — Principal investigator
First posted
Jan 24, 2022
Start date
Jan 5, 2019
Primary completion
Feb 20, 2022 (estimated)
Completion
Mar 30, 2022 (estimated)
Last update
Jan 24, 2022

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jan 2022. You cannot join it, but the record below documents what was studied.

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