An interventional study of STAR-MAP health coaching and Medication reminder tools in Hypertension, Medication Adherence and Behavior and Behavior Mechanisms, sponsored by Tulane University. Active, not recruiting at 5 sites in United States. Open to participants aged 40 Years and older. Per ClinicalTrials.gov, last updated 2026-10-01.
Sponsored by Tulane University · Not applicable, Interventional, and Prevention
Randomized controlled trial testing the efficacy of the Supporting Tailored Adaptive change and Reinforcement for Medication Adherence Program (STAR-MAP), a health coaching approach that aims to improve antihypertensive medication adherence, blood pressure control, and quality of life. Participants (n=402) >=40 years old with a diagnosis of hypertension, uncontrolled blood pressure, and low antihypertensive medication adherence will be recruited through a statewide health insurer, Blue Cross Blue Shield of Louisiana, and randomized to receive either interactive health coaching sessions with medication reminder tools (intervention) or medication reminder tools only (control) over one year. Data will be collected from participants at baseline, 6 months, 12 months, and 24 months using questionnaires, physical measurement (height, weight, blood pressure), a computer-based single-category implicit association test, and laboratory analysis of antihypertensive medication urinary metabolites.
6,114 studies on the registry are indexed under Hypertension; 912 are open to participants now.
This study's planned enrollment of 402 is above the median of 100 across 4,575 interventional studies indexed under Hypertension.
Browse Hypertension studies →Tulane University is the lead sponsor of 96 studies on the registry; 23 are open to participants now.
Of its 9 completed or terminated interventional studies of FDA-regulated products, 5 (56%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Interactive health coaching sessions and medication reminder tools
Behavioral: STAR-MAP health coaching · Behavioral: Medication reminder tools
Medication reminder tools only
Behavioral: Medication reminder tools
Interactive health coaching delivered in 11 sessions over one year; focusing on using adaptive change tactics to improve medication-taking behavior
Medication-taking reminder app and pillbox
Difference in proportion with PDC >=0.8 at 12 months
Proportion of days covered (PDC) calculated from pharmacy refill data
Time frame: 12 months
Difference in mean change in PDC, baseline to 12 months
Proportion of days covered (PDC) calculated from pharmacy refill data
Time frame: Baseline to 12 months
Difference in mean change in 4-item Krousel-Wood Medication Adherence Scale score, baseline to 12 months
Self-reported adherence measured by 4-item Krousel-Wood Medication Adherence Scale (K-Wood-MAS-4; minimum value: 0 (better adherence); maximum value: 4 (worse adherence))
Time frame: Baseline to 12 months
Difference in proportion with 4-item Krousel-Wood Medication Adherence Scale score <1 at 12 months
Self-reported adherence measured by 4-item Krousel-Wood Medication Adherence Scale (K-Wood-MAS-4; minimum value: 0 (better adherence); maximum value: 4 (worse adherence))
Time frame: 12 months
Difference in change in proportion with high adherence as measured by urine metabolite analysis, baseline to 12 months
Adherence determined by liquid chromatography tandem mass spectrometry analysis of urinary metabolites of antihypertensive medications
Time frame: Baseline to 12 months
Difference in proportion with controlled BP at 12 months
Controlled blood pressure (BP) defined as systolic BP \<130 mm Hg and diastolic BP \<80 mm Hg; BP measured using standardized protocol
Time frame: 12 months
Difference in mean change in SBP, baseline to 12 months
Systolic blood pressure (SBP) measured using standardized protocol
Time frame: Baseline to 12 months
Difference in mean change in DBP, baseline to 12 months
Diastolic blood pressure (DBP) measured using standardized protocol
Time frame: Baseline to 12 months
Difference in mean change in health-related quality of life scores, baseline to 12 months
Quality of life measured using 12-item Short Form Survey (SF-12); scores for eight subscales, Mental Component Summary, and Physical Component Summary calculated and compared (minimum: 0 (worse quality of life); maximum: 100 (better quality of life))
Time frame: Baseline to 12 months
Difference in mean change in 4-item Krousel-Wood Medication Adherence Scale score, baseline to 6 months
Self-reported adherence measured by 4-item Krousel-Wood Medication Adherence Scale (K-Wood-MAS-4; minimum value: 0 (better adherence); maximum value: 4 (worse adherence))
Time frame: Baseline to 6 months
Difference in proportion with 4-item Krousel-Wood Medication Adherence Scale score <1 at 6 months
Self-reported adherence measured by 4-item Krousel-Wood Medication Adherence Scale (K-Wood-MAS-4; minimum value: 0 (better adherence); maximum value: 4 (worse adherence))
Time frame: 6 months
Difference in change in proportion with high adherence as measured by urine metabolite analysis, baseline to 6 months
Adherence determined by liquid chromatography tandem mass spectrometry analysis of urinary metabolites of antihypertensive medications
Time frame: Baseline to 6 months
Difference in proportion with controlled BP at 6 months
Controlled blood pressure (BP) defined as systolic BP \<130 mm Hg and diastolic BP \<80 mm Hg; BP measured using standardized protocol
Time frame: 6 months
Difference in mean change in SBP, baseline to 6 months
Systolic blood pressure (SBP) measured using standardized protocol
Time frame: Baseline to 6 months
Difference in mean change in DBP, baseline to 6 months
Diastolic blood pressure (DBP) measured using standardized protocol
Time frame: Baseline to 6 months
Difference in mean change in health-related quality of life scores, baseline to 6 months
Quality of life measured using 12-item Short Form Survey (SF-12); scores for eight subscales, Mental Component Summary, and Physical Component Summary calculated and compared (minimum: 0 (worse quality of life); maximum: 100 (better quality of life))
Time frame: Baseline to 6 months
Difference in proportion with PDC >=0.8 at 24 months
Proportion of days covered (PDC) calculated from pharmacy refill data
Time frame: 24 months
Difference in mean change in PDC, baseline to 24 months
Proportion of days covered (PDC) calculated from pharmacy refill data
Time frame: Baseline to 24 months
Difference in mean change in 4-item Krousel-Wood Medication Adherence Scale score, baseline to 24 months
Self-reported adherence measured by 4-item Krousel-Wood Medication Adherence Scale (K-Wood-MAS-4; minimum value: 0 (better adherence); maximum value: 4 (worse adherence))
Time frame: Baseline to 24 months
Difference in proportion with 4-item Krousel-Wood Medication Adherence Scale score <1 at 24 months
Self-reported adherence measured by 4-item Krousel-Wood Medication Adherence Scale (K-Wood-MAS-4; minimum value: 0 (better adherence); maximum value: 4 (worse adherence))
Time frame: 24 months
Difference in change in proportion with high adherence as measured by urine metabolite analysis, baseline to 24 months
Adherence determined by liquid chromatography tandem mass spectrometry analysis of urinary metabolites of antihypertensive medications
Time frame: Baseline to 24 months
Difference in proportion with controlled BP at 24 months
Controlled blood pressure (BP) defined as systolic BP \<130 mm Hg and diastolic BP \<80 mm Hg; BP measured using standardized protocol
Time frame: 24 months
Difference in mean change in SBP, baseline to 24 months
Systolic blood pressure (SBP) measured using standardized protocol
Time frame: Baseline to 24 months
Difference in mean change in DBP, baseline to 24 months
Diastolic blood pressure (DBP) measured using standardized protocol
Time frame: Baseline to 24 months
Difference in mean change in health-related quality of life scores, baseline to 24 months
Quality of life measured using 12-item Short Form Survey (SF-12); scores for eight subscales, Mental Component Summary, and Physical Component Summary calculated and compared (minimum: 0 (worse quality of life); maximum: 100 (better quality of life))
Time frame: Baseline to 24 months
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is active, not recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Tulane University