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Status unknownNCT05182619Updated Jan 10, 2022

Stellate Block Versus Nimodipine Infusion for Traumatic Brain Injury

An Early Phase 1 interventional study of ultrasound-guided stellate ganglion block in Traumatic Brain Injury, sponsored by Sohag University. Status unknown. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-01-10.

Sponsored by Sohag University · Early Phase 1, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Dec 2021), so the status shown — last known as Not yet recruiting — may be out of date.
Phase
Early Phase 1
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
18 Years and older
Sex
All
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Study summary

the study is designed to perform an intervention for enhancement of cerebral blood flow in patients with traumatic brain injury showing vasospasm through transcranial doppler

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Conditions studied

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In context

Brain Injuries

2,113 studies on the registry are indexed under Brain Injuries; 385 are open to participants now.

This study's planned enrollment of 60 is above the median of 48 across 1,331 interventional studies indexed under Brain Injuries.

Browse Brain Injuries studies →

Lead sponsor

Sohag University is the lead sponsor of 1,183 studies on the registry; 612 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • patients more than 18 ys old with isolated head trauma and traumatic brain injury

Exclusion criteria

Exclusion Criteria:

    • Hemodynamic instability (mean ABP less than 70 mmHg)

      • History of severe systemic disease including cardiopulmonary failure or hepatorenal failure
      • Allergy to local anesthetics
      • Coagulation disorders
      • Abnormal neck structures disturbing normal anatomy as neck tumors
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Study design

Phase
Early Phase 1
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
60 participants (estimated)

Study arms

  • Active comparator
    ultrasoung guided stellate block

    stellate ganglion will have ultrasound-guided block via bupivacaine for sympathectomy and enhancement of cerebral blood flow

    Procedure: ultrasound-guided stellate ganglion block

  • Active comparator
    nimodipine infusion

    intravenous nimodipine will be given for enhancement of cerebral blood flow

    Procedure: ultrasound-guided stellate ganglion block

Interventions

  • Procedureultrasound-guided stellate ganglion block

    under aseptic conditions, using the ultrasound guidance, bilateral stellate ganglion block will be done using bupivacaine and betamethasone mixture, 8 ml volume will be given for each side

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What researchers measure

Primary outcomes

  1. enhancement of cerebral blood flow

    increased blood flow through middle cerebral artery and basilar artery measured by transcranial doppler ultraound

    Time frame: one week

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Study locations

No study locations are listed for this record.

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References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 10, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT05182619
Lead sponsor
Sohag University
Responsible party
Khaled Mohamed Abdelaal (assistant lecturer os anesthesia and intensive care, Sohag University) — Principal investigator
First posted
Jan 10, 2022
Start date
Jan 1, 2022 (estimated)
Primary completion
Jan 1, 2023 (estimated)
Completion
Apr 1, 2023 (estimated)
Last update
Jan 10, 2022

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Dec 2021. You cannot join it, but the record below documents what was studied.

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