An interventional study of Metabolic testing in Type 1 Diabetes, sponsored by University of Missouri-Columbia. Recruiting at 1 site in United States. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-10.
Sponsored by University of Missouri-Columbia · Not applicable, Interventional, and Basic science
The purpose of this research study is to understand how type 1 diabetes (T1D) increases the risk for cardiovascular diseases (heart attack and stroke). To this end, the investigators will compare apolipoprotein and triglyceride kinetics in people wtih T1D and healthy control participants.
Not required
3,522 studies on the registry are indexed under Diabetes Mellitus, Type 1; 577 are open to participants now.
This study's planned enrollment of 30 is below the median of 40 across 2,649 interventional studies indexed under Diabetes Mellitus, Type 1.
Browse Diabetes Mellitus, Type 1 studies →University of Missouri-Columbia is the lead sponsor of 357 studies on the registry; 70 are open to participants now.
Of its 42 completed or terminated interventional studies of FDA-regulated products, 28 (67%) have results posted.
Counted across the registry records on this site, refreshed daily.
Additional inclusion criteria for control subjects:
Additional inclusion criteria for subjects with T1DM:
Exclusion Criteria:
Healthy control group
Other: Metabolic testing
T1D group
Other: Metabolic testing
Participants will complete a metabolic testing protocol that includes intravenous infusion of stable isotope labeled tracers and blood sampling to determine lipoprotein kinetics
Apolipoprotein C turnover rate
Apolipoprotein C turnover rate will be assessed by using an intravenous stable isotope labeled amino acid infusion
Time frame: one time, at baseline (this is a cross-sectional, observational study, no intervention)
Triglyceride turnover rate
Triglyceride turnover rate will be assessed by using an intravenous stable isotope labeled glycerol infusion
Time frame: one time, at baseline (this is a cross-sectional, observational study, no intervention)
Apolipoprotein B-100 turnover rate
Apolipoprotein B-100 turnover rate will be assessed by using an intravenous stable isotope labeled amino acid infusion
Time frame: one time, at baseline (this is a cross-sectional, observational study, no intervention)
Apolipoprotein C concentration
Apolipoprotein C concentration
Time frame: one time, at baseline (this is a cross-sectional, observational study, no intervention)
Triglyceride concentration
Triglyceride concentration
Time frame: one time, at baseline (this is a cross-sectional, observational study, no intervention)
Apolipoprotein B-100 concentration
Apolipoprotein B-100 concentration
Time frame: one time, at baseline (this is a cross-sectional, observational study, no intervention)
Plan to share: Yes — De-identified data will be available upon reasonable request
No publications or documents are linked to this record.
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University of Missouri-Columbia