An observational study in Cholangiocarcinoma and Malignant Digestive System Neoplasm, sponsored by M.D. Anderson Cancer Center. Recruiting at 1 site in United States. Per ClinicalTrials.gov, last updated 2026-04-17.
Sponsored by M.D. Anderson Cancer Center · Observational
This study is to learn if certain risk factors (environmental, viral, behavioral, medical, and dietary), tumor markers, and genetic changes can predict the development and outcome of biliary tree cancers. Establishing biomarkers models from patients may help doctors to further understand how biliary tree cancer is affected by different treatments, and why some people's cancer responds differently than others.
PRIMARY OBJECTIVES:
I. To identify significant factors that may contribute to the etiology of biliary tree cancer.
II. To identify novel genetic loci that predispose to gallbladder cancers (GBC) and cholangiocarcinoma (CGC) diagnosis.
EXPLORATORY AND CORRELATIVE OBJECTIVES:
I. To use the collected blood and tissue materials for exploratory analysis to identify markers that predict prognosis of biliary tree cancers.
II. To correlate the identified markers with results of specific aim I and II to test the interaction between the identified markers with environmental and genetic factors.
OUTLINE:
Participants complete a questionnaire over 20 minutes. Participants also undergo collection of blood and leftover tissue samples.
914 studies on the registry are indexed under Cholangiocarcinoma; 286 are open to participants now.
This study's planned enrollment of 1,500 is above the median of 196 across 176 observational studies indexed under Cholangiocarcinoma.
Browse Cholangiocarcinoma studies →M.D. Anderson Cancer Center is the lead sponsor of 2,999 studies on the registry; 581 are open to participants now.
Of its 599 completed or terminated interventional studies of FDA-regulated products, 402 (67%) have results posted.
Counted across the registry records on this site, refreshed daily.
Patients with biliary tree cancer and healthy participants
Exclusion Criteria:
Participants complete a questionnaire over 20 minutes. Participants also undergo collection of blood and leftover tissue samples.
Procedure: Biospecimen Collection · Other: Questionnaire Administration
Undergo collection of tissue, and blood
Also known as: Biological Sample Collection, Biospecimen Collected
Complete questionnaire
Significant factors that may contribute to the etiology of biliary tree cancer
Time frame: through study completion, an average of 1 year
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M.D. Anderson Cancer Center