An interventional study of deep transcranial magnetic stimulation with H1 coil and High frequency deep transcranial magnetic stimulation with H1 coil in Treatment Resistant Schizophrenia Based on the DTMS, sponsored by Shanghai Mental Health Center. Status unknown at 1 site in China. Open to participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2021-12-22.
Sponsored by Shanghai Mental Health Center · Not applicable, Interventional, and Treatment
Negative symptoms and cognitive dysfunction are of importance for the prognosis of the patients of schizophrenia. Based on the hypothesis that deep transcranial magnetic stimulation(dTMS) on prefrontal cortex #PFC# could down-regulate the glutamate level of PFC and regulate the functional network in patients with treatment resistance schizophrenia,this research plan to utilise multimodal functional magnetic imaging method(including structural MRI,resting-state functional magnetic resonance imaging and 1H-MRS) to investigate therapeutic efficacy of high-frequency deep transcranial magnetic stimulation on SZ patients symptoms,as well as to elucidate the correlation between treatment effects and glutamate level of PFC
This study includes 87 treatment resistance schizophrenia patients. This study will investigate 1)abnormalities of the glutamate level of PFC in patients with schizophrenia compared to healthy controls by using 1H-MRS technique. 2)potential modulation effects of deep transcranial magnetic stimulation(dTMS) on prefrontal cortex function of patients with schizophrenia. 3)the therapeutic efficacy of dTMS on cognitive impairments and other psychotic symptoms of patients with schizophrenia by adopting cognitive function and psychotic symptoms evaluation,as well as to explore the optimal dTMS treatment pattern on cognitive function.
3,471 studies on the registry are indexed under Schizophrenia; 472 are open to participants now.
This study's planned enrollment of 87 is above the median of 70 across 2,872 interventional studies indexed under Schizophrenia.
Browse Schizophrenia studies →Shanghai Mental Health Center is the lead sponsor of 267 studies on the registry; 93 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
29 patients will be randomly allocated into this group,they will receive sham stimulation.
Device: deep transcranial magnetic stimulation with H1 coil
29 patients will be randomly allocated into this group,they will receive real stimulation.
Device: High frequency deep transcranial magnetic stimulation with H1 coil
29 patients will be randomly allocated into this group,they will receive real stimulation.
Device: iTBS deep transcranial magnetic stimulation with H1 coil
Sham deep transcranial magnetic stimulation on PFC .Duration:40 days.
high frequency(20Hz) deep transcranial magnetic stimulation on PFC .Duration:40 days.
iTBS deep transcranial magnetic stimulation on PFC .Duration:40 days.
Change from baseline in Positive and Negative Syndrome Scale(PANSS)
Change from baseline in Positive and Negative Syndrome Scale(PANSS) after dtms treat 40 days
Time frame: baseline,24 hours after the dTMS treatment,40 days
Change from baseline in MATRICS Consensus Cognitive Battery
MATRICS Consensus Cognitive Battery
Time frame: baseline,24 hours after the rTMS treatment,40 days
Change of PFC neurogenesis
Quantify neural stem cells in hippocampal by using H1-MRS
Time frame: baseline,24 hours after the dTMS treatment,40days
This study is status unknown, as verified in Nov 2021. You cannot join it, but the record below documents what was studied.
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Shanghai Mental Health Center