ClinicalTrials.gg
Active, not recruitingNCT05141604Updated Jul 2, 2026

Feasibility Test of Virtual Reality Obstacle Detection for Low Vision Walking

An interventional study of Field expansion view in Hemianopsia, Homonymous Hemianopia and Tunnel Vision, sponsored by Massachusetts Eye and Ear Infirmary. Active, not recruiting at 1 site in United States. Open to participants aged 14 Years and older. Per ClinicalTrials.gov, last updated 2026-07-02.

Sponsored by Massachusetts Eye and Ear Infirmary · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
15
Allocation
Not applicable
Ages
14 Years and older
Sex
All
01

Study summary

The investigators are developing a new test of pedestrian hazard detection in virtual reality (VR) head-mounted display (HMD) headset, which shows virtual oncoming pedestrians in 3D while subjects are walking in real-world environment, for evaluation of visual field expansion to improve mobility in people with visual field loss.

Read the detailed description

The investigators will develop a new pedestrian hazard detection test and conduct a single arm interventional clinical trial to evaluate simulated low vision assistive devices in a sample of field loss subjects. Pedestrian detection performance with and without field expansion information will be tested and compared. The study will include 1 to 4 visits (each 2 to 4 hours) depending on the number of trials and experimental conditions (e.g., with and without simulated assistive devices) the subject is comfortable completing. The time between visits may vary depending on scheduling constraints and availability. During each visit, the subject will complete a series of simulated collision avoidance trials in VR requiring the detection and natural avoidance of a colliding pedestrian (alongside non-colliding pedestrians) while physically walking through an empty corridor. The study will be considered minimal-risk since there will be no physical obstacles that present actual collision risks.

02

Conditions studied

  • Hemianopsia
  • Homonymous Hemianopia
  • Tunnel Vision
  • Visual Field Defect, Peripheral
  • Visual Field Constriction Bilateral
  • Visual Field Defect Homonymous Bilateral

Browse trials for

Keywords

  • walking
  • collision
  • field expansion
  • visual field loss
03

In context

Hemianopsia

63 studies on the registry are indexed under Hemianopsia; 24 are open to participants now.

This study's planned enrollment of 15 is below the median of 32 across 53 interventional studies indexed under Hemianopsia.

Browse Hemianopsia studies →

Lead sponsor

Massachusetts Eye and Ear Infirmary is the lead sponsor of 100 studies on the registry; 23 are open to participants now.

Of its 13 completed or terminated interventional studies of FDA-regulated products, 7 (54%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
14 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • At least 14 years of age (no upper age limit)
  • In sufficiently good health to be able to complete sessions lasting 2-3 hours
  • Able to understand English
  • Able to give voluntary,
  • Able to independently move short distances
  • Binocular vision parameters within normal limits (Stereopsis ≤ 100 arc sec on any stereo test)
  • Visual field loss, either peripheral field loss (\<30 degrees diameter) or hemianopic field loss (blind in half of visual field)
  • Better than 20/100 visual acuity in the worse eye

Exclusion criteria

Exclusion criteria:

  • Patients with any self-reported physical or mental disabilities, including cognitive dysfunction, balance problems, or other deficits that could impair their ability to respond to the stimuli presented in this study
  • Any person with a self-reported medical history (such as pacemaker use or photosensitive epilepsy) or physical condition listed on the device manual of the Oculus / HMD system used for the experiment as a
  • Any self-reported history of seizures (any type) in the last 6 months
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

Contraindication

A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.

05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
15 participants (estimated)

Study arms

  • Experimental
    Field expansion view

    Various configurations of field expansion views will be additionally displayed on HMD

    Other: Field expansion view

Interventions

  • OtherField expansion view

    Overlaid small window on HMD to show the part of the scene in the blind field into portions of the participants' remaining, seeing, field of vision

06

What researchers measure

Primary outcomes

  1. Response time

    During the pedestrian detection task, average response time to the colliding pedestrian with and without prisms

    Time frame: Through study completion, an average of four months

Secondary outcomes

  1. Head movement range

    During the pedestrian detection task, lateral and vertical head movement range to check the head scanning range

    Time frame: Through study completion, an average of four months

  2. Walking speed

    During the pedestrian detection task, the physical walking speed of the subject

    Time frame: Through study completion, an average of four months

  3. Pedestrian detection rate

    Proportion of simulated pedestrians detected (in HMD walking)

    Time frame: Through study completion, an average of four months

  4. Error rate

    Proportion of false alarms and missed targets to total targets

    Time frame: Through study completion, an average of four months

07

Study locations

1 site
  • Schepens Eye Research Institute
    Boston, Massachusetts 02114, United States
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 2, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05141604
Responsible party
Eli Peli (Senior Scientist, Massachusetts Eye and Ear Infirmary) — Principal investigator
First posted
Dec 2, 2021
Start date
May 17, 2022
Primary completion
Mar 30, 2025
Completion
May 31, 2027 (estimated)
Last update
Jul 2, 2026

Study contacts

Eli Peli, OD, MSc
principal investigator · Senior Scientist

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion