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CompletedNCT05131074Updated Mar 18, 2026

Collabree: A Remote Intervention to Improve the Regularity of Medication Intake

An interventional study of Collabree Mobile Phone Application Medication Adherence Booster and Collabree Mobile Phone Application Medication Adherence Booster (simplified version) in Hypertension and Medication Adherence, sponsored by Anjali Raja Beharelle. Completed at 1 site in Switzerland. Open to participants aged 50 Years and older. Per ClinicalTrials.gov, last updated 2026-03-18.

Sponsored by Anjali Raja Beharelle · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
144
Allocation
Randomized
Ages
50 Years and older
Sex
All
01

Study summary

This is a clinical study to improve the regularity of medication intake for high blood pressure. Adult women and men who are over 50 years old, who have received a prescription drug for high blood pressure from MediService, and who have to take at least 4 tablets per day (of which at least 1 dose of medication per day is for high blood pressure) can participate in this study.

The investigators intend to examine whether Collabree, a mobile phone application, is effective in supporting patients with hypertension to more successfully following their therapy plan in order to improve the regularity of medication intake.

The study includes a 90-day intervention phase and a 90-day follow-up. The study does not require any therapy adjustments and no visits to a study center are necessary. The participants conduct the study independently at home. Participants will also fill out questionnaires.

Participants are randomly assigned to one of 3 groups in a ratio of 1: 1: 1. Two of these groups will receive the Collabree mobile phone application.

02

Conditions studied

  • Hypertension
  • Medication Adherence

Keywords

  • Digital Health
  • Behavioral Change
03

In context

Hypertension

6,689 studies on the registry are indexed under Hypertension; 965 are open to participants now.

This study's enrollment of 144 is above the median of 90 across 4,995 interventional studies indexed under Hypertension.

Browse Hypertension studies →

Lead sponsor

This is the only study on the registry with Anjali Raja Beharelle as lead sponsor.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
50 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  1. Informed consent as documented by signature.
  2. Over 50 years of age on date of randomization.
  3. Patient received prescription medicine against hypertension by post from MediService.
  4. Prescribed a therapy against hypertension consisting of 4 or more tablets taken per day. At least 1 dose of medication per day must be against hypertension.
  5. Participant administers their own medications.
  6. Participant owns a smartphone with a data plan or constant internet access during the study reporting events and at home to use the application.
  7. Minimal required smartphone operating system is iOS 12 and Android 8 (Oreo).
  8. Adequate communication in German or Swiss-German (all study documentation will only be set to the German language).

Exclusion criteria

Exclusion Criteria:

  1. Inability to operate a mobile phone and the Collabree application.
  2. Inability to follow the procedures of the study, e.g., due to language problems, psychological disorders, dementia, etc.
  3. Enrollment of the Sponsor-Investigator, their family members, employees, and other dependent persons.
  4. Participation in another interventional clinical trial.
05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
144 participants (actual)

Study arms

  • Experimental
    Intervention Group A

    Patients receive the Collabree mobile phone application with a specific set of functions.

    Behavioral: Collabree Mobile Phone Application Medication Adherence Booster

  • Experimental
    Intervention Group B

    Patients receive the Collabree mobile phone application with a specific set of functions.

    Behavioral: Collabree Mobile Phone Application Medication Adherence Booster (simplified version)

  • No intervention
    Control Group

    Patients will not receive the Collabree application.

Interventions

  • BehavioralCollabree Mobile Phone Application Medication Adherence Booster

    Patients take part in a 90-day program to promote medication adherence and a 90-day follow-up through the Collabree application. Patients will receive more information as to the exact functions and use of the mobile phone application when the application is installed on their mobile phone.

  • BehavioralCollabree Mobile Phone Application Medication Adherence Booster (simplified version)

    Patients take part in a 90-day program to promote medication adherence and a 90-day follow-up through the Collabree application. Patients will receive more information as to the exact functions and use of the mobile phone application when the application is installed on their mobile phone.

06

What researchers measure

Primary outcomes

  1. Medication Adherence

    Difference between intervention Group A and the control group in mean medication adherence at endpoint (i.e. the endpoint visit at 90 days) as measured by pill count.

    Time frame: 90 days

Secondary outcomes

  1. Medication adherence (3 group comparison)

    Mean change from baseline in medication adherence (monitored by pill count) at endpoint for the intervention Group A vs. intervention Group B relative to the control group.

    Time frame: 90 days

  2. Self-reported medication adherence

    Mean change from baseline in in-app medication adherence (defined as the number of medications self-reported as "taken" during the intervention period of 90 days divided by the number of prescribed medications listed in the in-app medication plan in that same time period) at endpoint for the intervention Group A vs. intervention Group B relative to the control group.

    Time frame: 90 days

  3. Self-assessed medication adherence

    Mean change from baseline in the score on the Hill-Bone Scale (German version) questionnaire on medication adherence for the intervention Group A vs. intervention Group B relative to the control group at endpoint. The Hill-Bone Compliance to Blood Pressure Therapy Scale (German) scores can range from 14 to 56. A higher score means worse compliance.

    Time frame: 90 days

07

Study locations

1 site
  • Collabree AG
    Zurich, Canton of Zurich 8002, Switzerland
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 18, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT05131074
Lead sponsor
Anjali Raja Beharelle
Collaborators
MediService AG
Responsible party
Anjali Raja Beharelle (Study Sponsor-Investigator, Collabree AG) — Sponsor-investigator
First posted
Nov 23, 2021
Start date
Mar 10, 2022
Primary completion
Aug 23, 2024
Completion
Nov 24, 2024
Last update
Mar 18, 2026

Study contacts

Anjali Raja Beharelle, PhD
principal investigator · Collabree AG

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Feb 2024. You cannot join it, but the record below documents what was studied.

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