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CompletedNCT05125419Updated Jul 6, 2023

Homocysteine in Acute Coronary Syndrome

An observational study in Acute Coronary Syndrome, sponsored by Sohag University. Completed at 1 site in Egypt. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-07-06.

Sponsored by Sohag University · Observational

Study type
Observational
Model
Case-only
Time perspective
Cross-sectional
Enrollment
100
Ages
18 Years and older
Sex
All
01

Study summary

This study aims to determine the relation between high homocysteine levels and increased incidence of acute coronary syndrome in young patients

Read the detailed description

Cross sectional study to:

assess homocysteine level in young adult patients presenting with acute coronary syndrome

02

Conditions studied

  • Acute Coronary Syndrome
03

In context

Acute Coronary Syndrome

1,461 studies on the registry are indexed under Acute Coronary Syndrome; 267 are open to participants now.

This study's enrollment of 100 is below the median of 500 across 561 observational studies indexed under Acute Coronary Syndrome.

Browse Acute Coronary Syndrome studies →

Lead sponsor

Sohag University is the lead sponsor of 1,183 studies on the registry; 612 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

All patients presented with acute coronary syndrome admitted to coronary care unit of Sohag University hospital according to inclusion and exclusion criteria

Inclusion criteria

    • The patients who presented in the hospital with chest pain consistent with acute coronary syndrome with any of the following features:

      1. Electrocardiogram (ECG) changes:

        • ST elevation
        • ST depression
        • T wave inversion
        • recent left bundle branch block
      2. Troponin T elevation (Norma value \< 0.06)

        2- Age: -Between 18- 40 years (Group A) - Age > 40 years (Group B)

Exclusion criteria

Exclusion Criteria:

  1. Chest pain not consistent with acute coronary syndrome
  2. Chronic kidney disease (CKD)
  3. Rheumatic heart disease (RHD)
  4. Congenital heart disease
  5. Anemia
  6. Cancer
05

Study design

Observational model
Case-only
Time perspective
Cross-sectional
Enrollment
100 participants (actual)
Target follow-up
6 Months
Patient registry
Yes

Interventions

  • Diagnostic testHomocysteine level

    diagnostic test

    Also known as: HCY

06

What researchers measure

Primary outcomes

  1. Coronary care unit admission with acute coronary syndrome

    Acute coronary syndrome hospitalization and cardiovascular deathes and estimated hazard ratios (HR) by use of multivariable Cox regression models

    Time frame: From date of randomization up to 1 month

07

Study locations

1 site
  • Sohag University
    Sohag, Egypt
08

References and documents

Publications

  • Liu J, Quan J, Li Y, Wu Y, Yang L. Blood homocysteine levels could predict major adverse cardiac events in patients with acute coronary syndrome: A STROBE-compliant observational study. Medicine (Baltimore). 2018 Oct;97(40):e12626. doi: 10.1097/MD.0000000000012626. PubMed 30290636 ↗

Individual participant data

Plan to share: Undecided

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 6, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05125419
Lead sponsor
Sohag University
Responsible party
Mahmoud Abdelnasser Labib (Principal investigator, Sohag University) — Principal investigator
First posted
Nov 18, 2021
Start date
Nov 30, 2021
Primary completion
May 30, 2023
Completion
Jul 1, 2023
Last update
Jul 6, 2023

Study contacts

Mohammed E Amin, Lecturer
study chair · Sohag University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2023. You cannot join it, but the record below documents what was studied.

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