An observational study in Spontanous Fungal Peritonitis, sponsored by Sohag University. Completed at 1 site in Egypt. Per ClinicalTrials.gov, last updated 2023-05-12.
Sponsored by Sohag University · Observational
Spontaneous bacterial peritonitis (SBP) is an infection of the peritoneal cavity with no surgically treatable intra-abdominal source of infection. Spontaneous peritonitis is a potentially fatal complication in patients with advanced liver cirrhosis. It is estimated that 10-20 % of patients with cirrhotic ascites may develop spontaneous peritonitis, which is usually caused by a bacterial infection.
In contrast, spontaneous fungal peritonitis (SFP) is less well-recognized. SFP may be associated with higher mortality rates than SBP but therapeutic approaches are largely undefined. To this end, the epidemiology and outcomes of patients with SFP have only been documented sporadically aimed to evaluate the risk factors for the development of spontaneous fungal peritonitis (SFP), and the prognosis of SFP compared with SBP
Cross-sectional study
Studied population \& locality:
Patients with signs and symptoms suggestive of spontaneous peritonitis who will be admitted to Tropical medicine and Gastroenterology or Internal medicine departments in Sohag university hospitals during the period from september 2021 to december 2022 will be included in the study.
According to the results of ascitic fluid analysis, we will divide the patients into 2 groups:
Group (1): patients with spontaneous bacterial peritonitis (SBP). Group (2): patients with spontaneous fungal peritonitis (SFP).
Exclusion criteria:
Patients seropositive for human immunodeficiency virus (HIV) and patients undergoing continuous ambulatory peritoneal dialysis were excluded from this study.
Methods:
All included patients will be subjected to:
Fasting blood sugar Liver function tests. CBC.
Ethical considerations:
185 studies on the registry are indexed under Peritonitis; 25 are open to participants now.
This study's enrollment of 100 is below the median of 127 across 59 observational studies indexed under Peritonitis.
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Patients with signs and symptoms suggestive of spontaneous peritonitis who will be admitted to Tropical medicine and Gastroenterology or Internal medicine departments in Sohag university hospitals
Patients with signs and symptoms suggestive of spontaneous peritonitis who will be admitted to Tropical medicine and Gastroenterology or Internal medicine departments in Sohag university hospitals during the period from September 2021 to december 2022
Exclusion Criteria:
Patients seropositive for human immunodeficiency virus (HIV) and patients undergoing continuous ambulatory peritoneal dialysis were excluded from this study.
cirrhotic patients diagnosed with SBP
Diagnostic Test: ASCITIC FLUID CULTURE
irrhotic patients diagnosed with SFP
Diagnostic Test: ASCITIC FLUID CULTURE
Ten milliliters of ascitic fluid will be collected at the bedside and inoculated into aerobic and anaerobic blood culture bottles. Bacterial culture will be performed manually using MacConkey and blood agar plate
he risk factors for the development of spontaneous fungal peritonitis
number/percentage
Time frame: September 2021 to December 2022 will be included in the study.
Plan to share: No
This study is completed, as verified in May 2023. You cannot join it, but the record below documents what was studied.
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Sohag University