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CompletedNCT05116670Updated Mar 3, 2022

Comparison of Care Practices, Mortality and Morbidity of Very Preterm Infants Between Two Tertiary Centers in Northwest and South of China

An observational study in Morality, Morbidity;Newborn and Very Preterm Maturity of Infant, sponsored by Nanjing Medical University. Completed at 1 site in China. Open to participants aged 1 Day to 28 Days. Per ClinicalTrials.gov, last updated 2022-03-03.

Sponsored by Nanjing Medical University · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
807
Ages
1 Day to 28 Days
Sex
All
01

Study summary

Care practices, mortality and morbidity of very premature infants from two different tertiary centers were collected and compared, in order to discover areas for improvement where these two newborn centers can learn from each other.

Read the detailed description

This retrospective cohort study was conducted in two hospitals,Qinghai Red Cross Hospital and Jinan University affiliated Shenzhen Baoan Women's and Children's Hospital.Very premature infants born with a gestational age between 22+0 - 31+6 weeks admitted to both centers during 3 years from January 1, 2018 to December 31, 2020 were studied. In both centers, data including maternal characteristics, neonatal characteristics, obstetric practices, delivery room practices, and neonatal outcomes, were collected by data abstractors in each NICU. Anonymous data was transferred to Shenzhen and analyses were performed at the newborn center of SZH.

02

Conditions studied

  • Morality
  • Morbidity;Newborn
  • Very Preterm Maturity of Infant

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Keywords

  • care practices
  • mortality
  • morbidity
  • very preterm infant
  • comparison
03

In context

Premature Birth

2,554 studies on the registry are indexed under Premature Birth; 498 are open to participants now.

This study's enrollment of 807 is above the median of 112 across 777 observational studies indexed under Premature Birth.

Browse Premature Birth studies →

Lead sponsor

Nanjing Medical University is the lead sponsor of 169 studies on the registry; 51 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
1 Day to 28 Days
Sexes eligible
All
Sampling method
Non-probability sample

Study population

Very premature infants born with a gestational age between 22+0 - 31+6 weeks admitted to newborn centers of Qinghai Red Cross Hospital and Shenzhen Baoan Women's and Children's Hospital from Jan 1, 2018 to Dec 31, 2020.

Inclusion criteria

  • Very premature infants born with a gestational age between 22+0 - 31+6 weeks;
  • Admitted to both centers during 3 years from January 1, 2018 to December 31, 2020.

Exclusion criteria

Exclusion Criteria:

  • Infants not born at QHH or SZH (out born);
  • Infants who had major congenital anomalies;
  • Infants admitted after 7 days of life.
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
807 participants (actual)
Patient registry
No

Groups and cohorts

  • Qinghai Red Cross Hospital
  • Shenzhen Baoan Women's and Children's Hospital
06

What researchers measure

Primary outcomes

  1. mortality

    death during hospitalisation and death after withdrawing treatment

    Time frame: Jan 1,2018 - Dec 31,2020

  2. Major morbidity

    severe neurological injury, moderate to severe BPD, NEC or severe ROP

    Time frame: Jan 1,2018 - Dec 31,2020

07

Study locations

1 site
  • Shenzhen Baoan Women's and Children's Hospital
    Shenzhen, Guangdong 518000, China
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 3, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05116670
Lead sponsor
Nanjing Medical University
Responsible party
Zhangbin Yu (Clinical Professor#Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University) — Principal investigator
First posted
Nov 11, 2021
Start date
Oct 15, 2021
Primary completion
Dec 31, 2021
Completion
Dec 31, 2021
Last update
Mar 3, 2022

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2022. You cannot join it, but the record below documents what was studied.

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