An interventional study of Exercise and Ozone in Asthma, Asthma, Exercise-Induced and Exercise Induced Asthma, sponsored by University of British Columbia. Status unknown at 2 sites in Canada. Open to participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2022-06-02.
Sponsored by University of British Columbia · Not applicable, Interventional, and Basic science
Researchers found that impairments in the cardiopulmonary system caused by acute exposure to ozone were outweighed by repeated exposures to ozone. The goal of this study is to confirm there will be an adaptation similar to what was previously proved but in individuals with asthma and exercise-induced bronchoconstriction (EIB). The purpose is to examine adaptive responses in a randomized cross-over trial in which physically active individuals will perform submaximal exercise on five days in ozone and filtered air exposures separated by a washout period.
52 studies on the registry are indexed under Asthma, Exercise-Induced; 3 are open to participants now.
This study's planned enrollment of 40 is below the median of 47 across 40 interventional studies indexed under Asthma, Exercise-Induced.
Browse Asthma, Exercise-Induced studies →University of British Columbia is the lead sponsor of 1,339 studies on the registry; 259 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 1 (17%) have results posted.
Compared within Asthma, Exercise-Induced, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Asthma. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
From a breathing test (spirometry): how much air you can blow out in the first second. Often given as a percentage of what is expected for your age, height and sex.
FEV1
From a breathing test (spirometry): how much air you can blow out in the first second. Often given as a percentage of what is expected for your age, height and sex.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants of the experimental group will perform sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling 170ppb ozone delivered continuously during each exercise session.
Behavioral: Exercise · Other: Ozone
Participants of the sham group will also perform sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer similar to intervention. However, only in this group, the ozone generator will not be activated so that just filtered air will be delivered to the participant while performing each exercise session.
Behavioral: Exercise · Other: Filtere Air
Cycling at 60% of VO2max on a cycle ergometer for 30 minutes
Breathing 170ppb ozone
Breathing filtered air
Change in FEV1 from baseline to 10 minutes after exercise
Measurement of pulmonary function: forced exhaled volume in the first second (FEV1) in liters
Time frame: Measured at baseline and 10 minutes after each exercise bout
Change in FVC from baseline to 10 minutes after exercise
Measurement of pulmonary function: forced vital capacity (FVC) in liters
Time frame: Measured at baseline and 10 minutes after each exercise bout
Change in FEF25-75 from baseline to 10 minutes after exercise
Measurement of pulmonary function: forced expiratory flow at 25-75% of pulmonary volume in liters per second (L/s)
Time frame: Measured at baseline and 10 minutes after each exercise bout
Change in Pulse Wave Velocity (PWV) from baseline to 20 minutes after exercise
Velocity (in meters per second) at which the blood pressure pulse propagates through set points in the circulatory system
Time frame: Measured at baseline and 20 minutes after each exercise bout
Change in Fraction of exhaled nitric oxide (FeNO) from baseline to 5 minutes after exercise
Non-invasive airway inflammation biomarker (in part per billion, ppb)
Time frame: Measured at baseline and 5 minutes after each exercise bout
Plan to share: No
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This study is status unknown, as verified in May 2022. You cannot join it, but the record below documents what was studied.
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