An interventional study of high flow nasal cannula and Venturi mask in COPD, sponsored by The First Affiliated Hospital of Guangzhou Medical University. Status unknown at 1 site in China. Open to participants aged 40 Years to 80 Years. Per ClinicalTrials.gov, last updated 2021-10-28.
Sponsored by The First Affiliated Hospital of Guangzhou Medical University · Not applicable, Interventional, and Treatment
Early PR is thought to be effective in COPD patients recovering from acute exacerbation, while the effect of HFNC during exercise training in these patients remains unclear. The study may provide evidence of early PR in COPD patients recovering from acute exacerbation.
We hypothesize that HFNC may increases exercise time in COPD patients recovering from acute exacerbation compare to VM. A randomized, cross-over clinical trial in which either HFNC or VM may be used as an adjunct in 10-MST in random order, respectively, will be performed to compare the endurance time. The physiological effect of HFNC and VM during exercise will also be measured to explore the mechanism.
The First Affiliated Hospital of Guangzhou Medical University is the lead sponsor of 158 studies on the registry; 65 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
* Set FiO2 28% * Titrate the flow of HFNC at the highest tolerated value up to 60 L/min
Device: high flow nasal cannula
- Keep FiO2 constant with VM and HFNC during the two trial
Device: Venturi mask
HFNC provides humidified, heated, oxygen-enriched air at constant concentration with a flow up to 60L/min through a nasal cannula. It washouts the anatomical dead space and decreases the work of breathing.
VM is commonly used by COPD patients during exercise training.
Endurance time
Endurance time for 10 minute steping test
Time frame: 10 minute
Respiratory pattern
Respiratory pattern is calculated by the flow and time
Time frame: 10 minute
Work of breathing
Work of breathing is calculated by the transdiaphragmatic pressure
Time frame: 10 minute
Neural respiratory drive
Neural respiratory drive is calculated by diaphragm electromyogram
Time frame: 10 minute
Plan to share: No
No publications or documents are linked to this record.
This study is status unknown, as verified in Oct 2021. You cannot join it, but the record below documents what was studied.
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The First Affiliated Hospital of Guangzhou Medical University