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RecruitingNCT05091762Updated Oct 25, 2021

Effect of Physiological Ischemic Training on Patients With Atherosclerosis

An interventional study of exercise in Atherosclerosis, sponsored by Nanjing First Hospital, Nanjing Medical University. Recruiting at 1 site in China. Open to participants aged 18 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-10-25.

Sponsored by Nanjing First Hospital, Nanjing Medical University · Not applicable, Interventional, and Prevention

From the registry’s dates

  • Primary completion was expected by Dec 2025, 9 months ago, but the record still lists the study as recruiting.
  • Started Oct 2021; still recruiting 4 years 11 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
200
Allocation
Randomized
Ages
18 Years to 75 Years
Sex
All
01

Study summary

To study whether the resistance training with blood flow obstruction in patients in early atherosclerosis period can produce a beneficial effect on preventing atherosclerosis.

02

Conditions studied

  • Atherosclerosis

Browse trials for

Keywords

  • resistance training
03

In context

Atherosclerosis

1,567 studies on the registry are indexed under Atherosclerosis; 264 are open to participants now.

This study's planned enrollment of 200 is above the median of 106 across 882 interventional studies indexed under Atherosclerosis.

Browse Atherosclerosis studies →

Lead sponsor

Nanjing First Hospital, Nanjing Medical University is the lead sponsor of 213 studies on the registry; 106 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  1. LDL > 3.11mmol/l and less than 5.63mmol/l;
  2. No serious heart, blood vessel and other related diseases;
  3. There were no skeletal and muscular diseases affecting sports training;
  4. No regular exercise in the past half year (no more than 2 times a week, no more than 30 minutes each time);
  5. Smoking less than 1 pack / year, no history of drinking.

Exclusion criteria

Exclusion Criteria:

  1. Haven't other serious heart and vascular diseases other than hyperlipidemia and / or bones and muscles that affect sports training Diseases;
  2. Pregnant women and people with disabilities;
  3. Other circumstances determined by the researcher not suitable for the study.
05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
200 participants (estimated)

Study arms

  • No intervention
    Blank control group
  • Experimental
    Exercise group

    Behavioral: exercise

  • No intervention
    Hyperlipidemia group
  • No intervention
    Hyperlipidemia and medication group
  • Experimental
    Hyperlipidemia and exercise group

    Behavioral: exercise

  • Experimental
    Hyperlipidemia and medication and exercise group

    Behavioral: exercise

  • No intervention
    Routine treatment group
  • Experimental
    Routine treatment and exercise group

    Behavioral: exercise

Interventions

  • Behavioralexercise

    Upper limb resistance training with blood flow obstruction

06

What researchers measure

Primary outcomes

  1. Endothelium dependent vasodilation

    Percentage of the change

    Time frame: 8 weeks

  2. Blood lipid analysis results

    Content of total cholesterol, triglycerides, high density lipoprotein and low density lipoprotein

    Time frame: 8 weeks

Secondary outcomes

  1. The inflammatory state

    Content of NO, eNOS, iNOS, IFN-γ, IL-6, IL-10 in blood

    Time frame: 8 weeks

  2. Endothelial repair function

    eNOSmRNA, iNOSmRNA, EPCs in blood

    Time frame: 8 weeks

07

Study locations

1 of 1 sites recruiting
  • Nanjing First Hospital
    Nanjing, Jiangsu 210006, China
    Recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 25, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05091762
Lead sponsor
Nanjing First Hospital, Nanjing Medical University
Responsible party
linaicui (Principal Investigator, Nanjing First Hospital, Nanjing Medical University) — Principal investigator
First posted
Oct 25, 2021
Start date
Oct 12, 2021
Primary completion
Dec 31, 2025 (estimated)
Completion
Dec 31, 2025 (estimated)
Last update
Oct 25, 2021

Study contacts

Aicui Lin, PhD
Contact
linaicui@126.com
+8615305179718
JunXia Zhang, PhD
Contact
15850770739@126.com
+8615850770739
Aicui Lin, PhD
study chair · Nanjing First Hospital, Nanjing Medical University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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