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RecruitingNCT07153263Updated Aug 28, 2026

Local Anaesthetic Spread and Sensory Block Range of the Retro-superior Costotransverse Ligament Space Block

An interventional study of Ultrasound-guided retro-SCTLB and Ultrasound-guided TPVB in Pulmonary Nodules and Nerve Block, sponsored by Nanjing First Hospital, Nanjing Medical University. Recruiting at 2 sites in China. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-08-28.

Sponsored by Nanjing First Hospital, Nanjing Medical University · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
50
Allocation
Randomized
Ages
18 Years to 80 Years
Sex
All
01

Study summary

The aim of this clinical trial is to investigate the effects of local anesthetic diffusion range and sensory block range during retro-SCTLB(retro superior costotransverse ligament space block) and TPVB(thoracic paravertebral block) in patients undergoing CT-guided lung nodule localization. The main issue of the study is to determine the differences in the diffusion range and sensory block range of local anesthetics between the retro-SCTLB and TPVB nerve block methods.

Read the detailed description

Fifty patients were selected to undergo CT guided puncture localization of lung nodules under local anesthesia, and the patients were divided into groups using a computer-generated random number in a ratio of 1:1. To ensure objectivity, a nurse who was not involved in the study prepared a sealed opaque envelope containing grouping information. Patients were randomly divided into two groups: the retro-SCTLB group (group R, 25 patients), and the TPVB group (group T, 25 patients). All patients underwent ultrasound guided retro-SCTLB or TPVB before CT-guided nodule localization. Ultrasound-guided retro-SCTLB method: Using an ultrasound low-frequency convex array probe (1-6 MHZ, Sonosite, USA), the probe was placed parallel to the spine 2-3cm outside the spinous process of the fifth thoracic vertebra, on the surface of the transverse process tip. First, the probe was placed above the rib and costo-transverse process joint and observed from the inside out to clearly show the spinous process, lamina, transverse process and rib. Then, the probe was gently moved towards the caudal side. Until the sound shadows of the ribs and transverse processes disappear and inferior articular processes appear on the medial side, and when high-echo superior ligaments of the costal transverse processes appear behind the paravertebral space and anterolateral of the inferior articular processes, then gently rotate the outer edge of the probe towards the caudal side and a low-echo area can be seen behind the superior ligaments of the costal transverse processes, which is the target area. Then, using a long oblique plane puncture needle, with the in-plane technique, insert the needle from the outer side of the probe. When the needle tip reaches the target area, use the water separation technique to inject 1ml of normal saline to confirm the needle tip position, then inject 20ml of local anesthetic solution (0.375% ropivacaine 10ml+ iohexol 10ml) within 1 minute; Ultrasound-guided TPVB: Using an ultrasound low-frequency convex array probe (1-6 MHZ, Sonosite, USA), the probe is placed perpendicularly to the spine at the fifth thoracic vertebra on the midline of the trunk. First, the spinous process is identified, and then the ultrasound probe is gradually moved towards the surgical side. Structures such as the transverse process, pleura, and intercostal intima are visible. At this point, the ultrasound probe is moved parallel to the caudal side. The area between the parietal pleura, intercostal endometrium and transverse process is the target area for injection. Then, using a short inclined plane puncture needle, using the in-plane technique, the needle is inserted from the outside of the probe. When the needle tip reaches the target position, 1ml of normal saline is injected using the water separation technique to confirm the needle tip position. Then 20ml of local anesthetic solution (0.375% ropivacaine 10ml+ iohexol 10ml) is injected, and the injection is completed in 1 minute. 15 minutes after the block was completed, CT scans were performed and punctures were located, followed by three-dimensional reconstruction. Observe and record the local anesthetic solution: 1. The range of diffusion to the cranial and caudal side; 2 The range of diffusion to the intercostal space 3; The range of diffusion to the paravertebral space; 4. The range of diffusion to the epidural space; 5. The range of diffusion to the intervertebral foramen; 6. The range of diffusion to the anterolateral vertebrae (sympathetic ganglion).

02

Conditions studied

  • Pulmonary Nodules
  • Nerve Block

Keywords

  • nerve block
  • TPVB
  • ITPB
  • rSCTL
03

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

Patients scheduled for CT-guided lung nodule localization under local anesthesia will be selected

  1. aged 18-80 years
  2. BMI 18-30 kg/m²
  3. ASA classification I-III

Exclusion criteria

Exclusion Criteria:

  1. Allergy to the study drug or local anesthetic;
  2. History of opioid abuse;
  3. Pre-existing skin infection at the puncture site of ITPN or TPVB;
  4. Peripheral infectious neuropathy;
  5. Dysfunction of blood coagulation
04

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Investigator, Outcomes assessor)
Enrollment
50 participants (estimated)

Study arms

  • Experimental
    retro-SCTLB group

    A total of 20 ml of the local anesthetic solution (0.375% ropivacaine 10ml+ iohexol 10ml) is injected in the retro-superior costotransverse ligament space in the retro-SCTLB group within 60 seconds.

    Procedure: Ultrasound-guided retro-SCTLB

  • Experimental
    TPVB group

    A total of 20 ml of the local anesthetic solution (0.375% ropivacaine 10ml+ iohexol 10ml) is injected in the paravertebral space in the TPVB group within 60 seconds.

    Procedure: Ultrasound-guided TPVB

Interventions

  • ProcedureUltrasound-guided retro-SCTLB

    Patients undergoing CT-guided lung nodule localization were selected for the study. Before the surgery, the retro-SCTLB was performed under ultrasound guidance.

  • ProcedureUltrasound-guided TPVB

    Patients undergoing CT-guided lung nodule localization were selected for the study. Before the surgery, the TPVB was performed under ultrasound guidance.

05

What researchers measure

Primary outcomes

  1. Spread of local anesthetic into the paravertebral space

    Observation of incidence and thoracic level of local anesthetic spread into the paravertebral space with CT by a researcher who was blinded to group allocation

    Time frame: 15 minutes after completion of the nerve block

Secondary outcomes

  1. The range of the local anesthetic spreads to the intercostal space

    Observation of incidence and thoracic level of local anesthetic spread into the intercostal space with CT by a researcher who was blinded to group allocation

    Time frame: 15 minutes after completion of the nerve block

  2. Observation of local anesthetic spread cephalocaudally in the erector spinae plane

    Observation of incidence and thoracic level of local anesthetic spread into the erector spinae plane cephalocaudally with CT by a researcher who was blinded to group allocation.

    Time frame: 15 minutes after completion of the nerve block

  3. The range of the local anesthetic spread to the epidural space

    Observation of incidence and thoracic level of local anesthetic spread into the epidural space with CT by a researcher who was blinded to group allocation

    Time frame: 15 minutes after completion of the nerve block

  4. The range of the local anesthetic spread to the anterolateral vertebrae (sympathetic ganglion).

    Observation of incidence and thoracic level of local anesthetic spread into the anterolateral vertebrae (sympathetic ganglion) with CT by a researcher who was blinded to group allocation

    Time frame: 15 minutes after completion of the nerve block

  5. Assessment of skin sensory block with ice

    The sensation of skin to cold was assessed with ice. The area includes the anterior chest wall (midclavicular line), lateral chest wall (posterior axillary line), and posterior chest wall. The sensation was graded as 0 (no sensation), 1 (decreased sensation), or 2 (normal). A sensory block of the dermatome was considered to be achieved if the grade was either 0 or 1.

    Time frame: 15 minutes after completion of the nerve block

  6. The range of the local anesthetic spread to the intervertebral foramen

    Observation of incidence and thoracic level of local anesthetic spread into the intervertebral foramen with CT by a researcher who was blinded to group allocation

    Time frame: 15 minutes after completion of the nerve block

06

Study locations

2 of 2 sites recruiting
  • Tao Shan
    Nanjing, Jiangsu 210006, China
    Recruiting
  • Nanjing First Hospital
    Nanjing, China
    Recruiting
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT07153263
Lead sponsor
Nanjing First Hospital, Nanjing Medical University
Responsible party
Tao Shan (Attending physician, Nanjing First Hospital, Nanjing Medical University) — Principal investigator
First posted
Sep 3, 2025
Start date
Sep 12, 2025
Primary completion
Sep 15, 2026 (estimated)
Completion
Sep 30, 2026 (estimated)
Last update
Aug 28, 2026

Study contacts

Tao Shan
Contact
shantao2021@163.com
+8618852095135
Tao Shan
study chair · Nanjing First Hospital, Nanjing Medical University

Oversight

FDA-regulated drug
No
FDA-regulated device
No
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