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RecruitingNCT05091645Gr-GFIUpdated May 7, 2026

Translation and Cultural Adaptation of the Groningen Frailty Indicator (GFI) in Patients With Hip Fracture

An observational study in Frailty Syndrome and Hip Fractures, sponsored by University of Thessaly. Recruiting at 1 site in Greece. Open to participants aged 65 Years and older. Per ClinicalTrials.gov, last updated 2026-05-07.

Sponsored by University of Thessaly · Observational

From the registry’s dates

  • Started Feb 2022; still recruiting 4 years 7 months later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
89
Ages
65 Years and older
Sex
All
01

Study summary

This study attempts to the translation and the cultural adaptation of the Groningen Frailty Indicator (GFI) questionnaire in the Greek population in patients suffering from hip fracture.

Read the detailed description

Frailty indicates a state of vulnerability in terms of poor health outcomes, such as mortality, hospitalization, institutionalization and loss of function in one or more domains (i.e. physical, psychological, cognitive and social domains). Frailty is not only associated with poor quality of life and life satisfaction but also has an effect on health care demands, as the number of frail people in our aging population will increase.

Current literature suggests that frailty is a common condition among elderly patients with hip fracture. Ageing has been associated with a decline in physiological reserves which impedes the body's ability to withstand and recover from minor and major challenges, such as the hip fracture. Hence, accurate diagnosis of frailty seems mandatory. The Groningen Frailty Indicator (GFI) questionnaire is a feasible, reliable and valid self-assessment tool.

This study will provide the first official Greek translation and cultural adaptation of the GFI according to the ISPOR (International Society for Pharmacoeconomics and Outcomes Research) guidelines.

02

Conditions studied

  • Frailty Syndrome
  • Hip Fractures

Keywords

  • Frailty Syndrome
  • Hip fractures
  • Cultural adaptation
  • Translation
03

In context

Frailty

1,199 studies on the registry are indexed under Frailty; 430 are open to participants now.

This study's planned enrollment of 89 is below the median of 223 across 496 observational studies indexed under Frailty.

Browse Frailty studies →

Lead sponsor

University of Thessaly is the lead sponsor of 188 studies on the registry; 44 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
65 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with hip fractures undergoing surgery

Inclusion criteria

  • adult patients over 65 years old with hip fractures undergoing surgery
  • an ASA (American Society of Anesthesiologists) PS (physical status) I to III
  • non-institutionalized
  • able to communicate orally or in writing
  • consent to participate

Exclusion criteria

Exclusion Criteria:

  • refused to participate
  • pathological hip fractures
  • institutionalized
  • patients with hip fracture treated conservatively
  • patients with severe cognitive dysfunction
  • patients with insufficient knowledge of the Greek language
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
89 participants (estimated)
Patient registry
No

Groups and cohorts

  • Hip fracture_GFI

    Greek patients with hip fracture assessed for frailty syndrome with the adapted for the greek population GFI questionnaire

    Other: GFI

Interventions

  • OtherGFI

    Two trained raters who will be blinded and will have no access to each other's evaluation, will administer the GFI questionnaire within 24 hours of patients' hospital admission.

06

What researchers measure

Primary outcomes

  1. Translation and Cultural adaptation of the Greek version of Groningen Frailty Indicator (GFI) questionnaire

    Translation and Cultural adaptation of the Greek version of GFI

    Time frame: Within 24 hours of the hospital admission

Secondary outcomes

  1. Incidence of frailty syndrome

    Incidence of frailty syndrome in our study sample

    Time frame: Baseline (On admission)

07

Study locations

1 of 1 sites recruiting
  • University of Thessaly
    Larissa, 41335, Greece
    • Eleni Arnaoutoglou, MD, PhD · Contact · earnaout@gmail.com · +306974301352
    • Maria Ntalouka, MD, PhD · Contact · maria.ntalouka@icloud.com · +306973688099
    • Eleni Arnaoutoglou, MD, PhD · Principal investigator
    • Maria Ntalouka, MD, PhD, M.Sc. · Principal investigator
    • Fragkiskos Angelis, MD, M.Sc. · Principal investigator
    • Michael Hantes, MD, PhD · Principal investigator
    Recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 7, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05091645
Lead sponsor
University of Thessaly
Responsible party
Elena Arnaoutoglou (Professor of Anesthesiology, University of Thessaly) — Principal investigator
First posted
Oct 25, 2021
Start date
Feb 25, 2022
Primary completion
Sep 30, 2026 (estimated)
Completion
Nov 15, 2026 (estimated)
Last update
May 7, 2026

Study contacts

Eleni Arnaoutoglou, MD, PhD
Contact
earnaout@gmail.com
+306974301352
Maria Ntalouka, MD, PhD, MSc
Contact
maria.ntalouka@icloud.com
+306973688099
Eleni Arnaoutoglou, MD, PhD
principal investigator · University of Thessaly
Michael Hantes, MD, PhD
principal investigator · University of Thessaly

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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