An observational study in Hypernatremia and Critical Illness, sponsored by Catharina Ziekenhuis Eindhoven. Status unknown at 1 site in Netherlands. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-10-27.
Sponsored by Catharina Ziekenhuis Eindhoven · Observational
Hypernatremia is frequently encountered in patients admitted to the Intensive Care Unit (ICU) and associated with increased mortality and length of stay. Previous studies focused on predictors in the development and recovery of hypernatremia by including amount and types of administered medication, fluid balance, laboratory results and changes in vital signs. However, data of larger populations or data on infusion rates, fluid and sodium balance or renal replacement therapy is lacking. The predecessor of this study was the HYPNIC trial which found that increased sodium load en decreased sodium excretion preceded hypernatremia development, but was lacking information on the first 48 hours, fluid balances were manually collected before a new data collection system was introduced and was suffering from substantial amounts of missing data and small population for trend analysis.
This study aims to provide better insight in the development and recovery of hypernatremia while paying attention to the limitations from the HYPNIC trial.
All patients admitted to the Intensive Care Unit.
Exclusion Criteria:
For every patient in ICU, a daily morning urine sample will be collected from the already collected urine via catheter.
For a subgroup of 30 sedated patients, 24 hour urine collection will be collected. In addition, every 2 hours a 10ml urine sample will be collected.
Hypernatremia
After one year of collecting data on fluid and sodium balances, the patients who developed hypernatremia during their admission in the Intensive Care Unit will be compared to the patients who remained normonatremic throughout their ICU admission.
Time frame: During admission in ICU
24 hour urine replacement for spot-checks
Assessing whether 24 hour urine collection can be replaced by spot-check measurements of urine by comparing both 24 hour urine and 2 hourly urine samples
Time frame: 24 hours
Plan to share: Undecided
This study is status unknown, as verified in Oct 2021. You cannot join it, but the record below documents what was studied.
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Catharina Ziekenhuis Eindhoven