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RecruitingNCT05076643Updated Aug 27, 2024

Biomarkers, TCM Body Constitution, Dietary Pattern and Psychological Factors in Predicting Depression

An observational study in Depression, sponsored by Universiti Tunku Abdul Rahman. Recruiting at 1 site in Malaysia. Open to participants aged 18 Years to 30 Years. Per ClinicalTrials.gov, last updated 2024-08-27.

Sponsored by Universiti Tunku Abdul Rahman · Observational

From the registry’s dates

  • Primary completion was expected by Dec 2024, 1 year 10 months ago, but the record still lists the study as recruiting.
  • Started Mar 2022; still recruiting 4 years 6 months later.
Study type
Observational
Model
Other
Time perspective
Cross-sectional
Enrollment
397
Ages
18 Years to 30 Years
Sex
All
01

Study summary

This study aims to determine the predictors of depression among university students in Universiti Tunku Abdul Rahman (UTAR) Sungai Long Campus.

Read the detailed description

University students are a high at risk group for development of depression. Identifying the determinants of depression could help in the diagnosis and treatment of this disorder. This study will incorporate questionnaire and blood sample data collection procedures on 397 subjects. Written consent will be obtained from the subjects. Eligible subjects will be given self-administered questionnaires which include Patient health questionnaire (PHQ-9), Constitution in Chinese medicine questionnaire (CCMQ), Dysfunctional Attitude Scale (DAS), Depression Anxiety Stress Scales (DASS-21) - stress and anxiety subscales, Perceived stress scale-10 (PSS-10), Rosenberg self-esteem scale (RSES), and Food frequency questionnaire (FFQ). Once the subjects completed the questionnaires, blood samples will be collected from them by a trained phlebotomist. In addition, 10 most high at risk of depression subjects (with PHQ-9 scores 10 and above) and 10 healthy subjects (with PHQ-9 scores lower than 10) will be selected randomly for protein expression to further identify the proteins that significantly expressed among them.

02

Conditions studied

03

In context

Depression

8,055 studies on the registry are indexed under Depression; 1,643 are open to participants now.

This study's planned enrollment of 397 is above the median of 160 across 1,084 observational studies indexed under Depression.

Browse Depression studies →

Lead sponsor

Universiti Tunku Abdul Rahman is the lead sponsor of 35 studies on the registry; 9 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 30 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

University students

Inclusion criteria

  • Malaysian citizen
  • Able to read and communicate in English

Exclusion criteria

Exclusion Criteria:

  • Special education disability (deaf and blind)
  • Physical support
  • History of infectious diseases
05

Study design

Observational model
Other
Time perspective
Cross-sectional
Enrollment
397 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna

Groups and cohorts

  • University students

    University students in Universiti Tunku Abdul Rahman Sungai Long Campus

06

What researchers measure

Primary outcomes

  1. Genetic, TCM body constitution, psychological factors and dietary pattern are significant predictors for depression among university students.

    Univariate and multivariate logistic regression will be performed.

    Time frame: Baseline

Secondary outcomes

  1. Prevalence of depression among university students.

    Patient Health Questionnaire (PHQ-9): Non depressed = 0 - 9; Depressed = 10 - 27

    Time frame: Baseline

  2. Protein significantly expressed between depressed and non-depressed students.

    Liquid chromatography-mass spectrometry (LC-MS) will be performed.

    Time frame: Baseline

07

Study locations

1 of 1 sites recruiting
  • Universiti Tunku Abdul Rahman
    Kajang, Selangor 43000, Malaysia
    Recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 27, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05076643
Lead sponsor
Universiti Tunku Abdul Rahman
Responsible party
Foo Chai Nien (Assistant Professor, Universiti Tunku Abdul Rahman) — Principal investigator
First posted
Oct 13, 2021
Start date
Mar 17, 2022
Primary completion
Dec 2024 (estimated)
Completion
Dec 2024 (estimated)
Last update
Aug 27, 2024

Study contacts

Chai Nien Foo
Contact
foocn@utar.edu.my
+60123167252
Chai Nien Foo
principal investigator · Universiti Tunku Abdul Rahman

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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