An interventional study of urine sample and Blood and urine sample in Asymptomatic Bacteriuria, Frailty and Geriatric Syndrome, sponsored by Universitair Ziekenhuis Brussel. Completed at 1 site in Belgium. Open to participants aged 70 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-03-28.
Sponsored by Universitair Ziekenhuis Brussel · Not applicable, Interventional, and Diagnostic
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Among 24 studies in Frailty with a site in Belgium — 8 open to participants now, 9 under way, none of them phase 3. Frailty · Belgium.
Among the 24 studies in Frailty with a site in Belgium, this one is the 13th largest by enrollment of the 16 interventional ones that give a count, is one of 2 that started in 2021, is one of 16 with no phase, and was the 16th registered.
1,284 studies on the registry are indexed under Frailty; 451 are open to participants now.
Browse Frailty studies →8 of the 24 studies in Frailty with a site in Belgium are open now. Recruiting first, the newest first:
Groupe Hospitalier du Havre · Sites in Belgium, France
Ages 50+
Centre Hospitalier Universitaire Saint Pierre · Sites in Belgium
Ages 65–74
University Hospital, Ghent · Sites in Belgium, Austria, Finland and 5 more countries
Ages 18+
Université Catholique de Louvain · Sites in Belgium
Ages 65+
Universitair Ziekenhuis Brussel · Sites in Belgium
Ages 70+
A study can be open while its sites in Belgium have not opened yet or have stopped. Only those recruiting at a site in Belgium →
Of the 299 Frailty studies recruiting now, 235 (79%) set no upper age limit and 9 (3%) stop at 75 or younger; 7 take children under 18; 66 take healthy volunteers.
This study: 70 Years and older · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
24 studies; the count open now beside each. This study's row is marked.
First in 2010; this study’s year is marked. 2 started in 2021.
This study's enrollment of 36 is below the median of 81 across 767 interventional studies indexed under Frailty.
Median enrollment 110 across the 16 interventional studies, 155 across the 8 observational. Of the 12 that completed or were terminated, 0 (0%) have results posted.
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None of the 24 has an industry lead sponsor. The 10 most frequent:
Universitair Ziekenhuis Brussel is the lead sponsor of 375 studies on the registry; 107 are open to participants now.
Universitair Ziekenhuis Brussel has 2 studies filed under Frailty — fewer than ten, so there is no comparison to draw.
2 of the studies in Frailty with a site in Belgium that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT05946109Universitair Ziekenhuis BrusselEffect of an Exercise Program for Frail Older Adults | 2026-11-30 |
| NCT07026773University Hospital, GhentValidity of ICU Clinician's Appraisal of Proportionality in CPR | 2026-12-30 |
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Among the 24 studies in Frailty with a site in Belgium, from their registry updates:
Nothing recorded among them since 2026-09-25.
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The population is aging. Aged people are more prown to develop frailty. The causes of frailty are multifactorial and are being investigated in research settings. Cardiovascular diseases, inflammaging and changes in microbiota have been associated with frailty and geriatric syndrome. The prevalence of asymptomatic bacteriuria and SIADH-related hyponatremia is also important in aging and associated with inflammaging. The aim of this study is to examine, if asymptomatic bacteriuria and SIADH-related hyponatremia could be markers for frailty and geriatric syndrome.
The demographic evolution represents a challenge for the general public health. The global population, especially in the developed countries, is aging. Aging is associated with a decrease of physio-logical functions leading to frailty. Frailty is an important concept in geriatric medicine: it is a biological syndrome of decreased reserve and resistance to stressors resulting from cumulative decline across multiple physiological systems (like osteopenia, sarcopenia, dysregulation of hypothalamic axis ...). Factors that lead to frailty influence each other and can be self-perpetuating. Frailty is a geriatric syndrome but there are a lot of other geriatric syndrome such as falls, undernutrition,... When young people are sick, they present mostly more than one symptom who can be referred to one disease or one cause. In contrast, geriatric patients will present one symptom, such as confusion, fall, undernutrition,... which can be referred to multifactorial causes or diseases. This is the concept of geriatric syndrome.
Frailty or geriatric syndrome has been related to inflammaging. Inflammaging, characterized by an increase of circulating cytokines such as interleukin (IL)-6 and acute phase proteins, is a feature of immunosenescence. This process of immunosenescence is suggested to participate in the pathogene-ses of frailty and geriatric syndromes. The possible origins of inflammaging are multifactorial and controversies still exist: cardiovascular (CV) diseases, depression and chronic cytomegalovirus (CMV) infections are associated with this pro-inflammatory state. These comorbidities are highly prevalent in geriatric patients and could therefore contribute to the association between low-grade inflammation, frailty and geriatric syndromes.
The intestinal barrier and microbiota are associated with frailty and inflammaging. Multiple potential pathways exist through which the gut microbiota can provoke inflammaging (through TLR, stimulation of immune cells, translocation, endotoxines et cetera). In the same way of thinking, asymptomatic bacteriuria could also be responsible of inflammaging and frailty. The prevalence of asymptomatic bacteriuria is increased with aging and in patient with diabetes. It has also been shown to be associated with chronic inflammation (sTNFR and TNFα), increased WBCC and neutrophils. To our knowledge, it is unknown if asymptomatic bacteriuria is associated with frailty.
Hyponatremia is highly prevalent in hospitalized patients. SIADH-related hyponatremia represents 1/3 of the causes of hyponatremia. The incidence of SIADH related hyponatremia is believed to be higher in older people. It is associated with an increased risk of falls, confusion and mortality. The physiological balance between water and salt changes with aging. SIADH is classified as an euvo-lemic status; however, it is caused by an excess of water. The inappropriate secretion of vasopressin( ADH=anti-diuretic hormone) increases the expression of the aquaporins in the renal tubules. These aquaporines increase the reabsorption of water resulting in an altered ratio of reabsorption of water and Salt, leading to hyponatremia. SIADH-related hyponatremia is also associated with inflammation. IL-6 and IL-1β are able to stimulate the pituitary-hypothalamic axis to secrete vasopressin. SIADH related hyponatremia could be also a sign of inflammaging and related with frailty.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
patients with the geriatric syndrome who will be recruited at the geriatric out patient clinic
Diagnostic Test: urine sample · Diagnostic Test: Blood and urine sample
healthy aged people defined as in the modified SENIEUR protocol who will be recruited by an extern call thanks UZ Brussel website of thanks to staff's knowledge
Diagnostic Test: urine sample · Diagnostic Test: Blood and urine sample
Each participant will give a urine sample for diagnose of asymptomatic bacteriuria
Each participant will give a urine and blood sample for diagnose of SIADH
asymptomatic bacteriuria
If the presence of an asymptomatic bacteriuria is associated with frailty or the geriatric syn-drome
Time frame: At baseline
SIADH
If the presence of SIADH-related hyponatremia is associated with frailty or geriatric syn-drome
Time frame: At baseline
SIADH and inflammaging
If the presence of SIADH-related hyponatremia is associated with a low grade chronic in-flammation as demonstrated by a raised c-reactive protein (CRP).
Time frame: At baseline
Plan to share: No
Ran from Oct 2021 to primary completion in Nov 2024, 37 months.
Of 513 non-industry interventional studies with no phase under Frailty, half reached primary completion within 22 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 39. This study's 37 months is above that.
Counting every sponsor, half of 517 studies reached it within 22 months; a quarter within 10 and three quarters within 39.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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