An interventional study of BRIDGE Intervention and Service as Usual in Borderline Personality Disorder, sponsored by NHS Greater Glasgow and Clyde. Status unknown at 1 site in United Kingdom. Open to participants aged 14 Years to 24 Years. Per ClinicalTrials.gov, last updated 2024-04-26.
Sponsored by NHS Greater Glasgow and Clyde · Not applicable, Interventional, and Other
The BRIDGE project: A feasibility randomised controlled trial of brief, intensive assessment and integrated formulation for young people (age 14-24) early in the course of borderline personality disorder.
This project is the first step in testing a new intervention programme, called BRIDGE (Brief, Intensive Assessment and Integrated Formulation), for young people early in the course of Borderline Personality Disorder (BPD). The BRIDGE Project will help us find out whether we can do a much bigger study in the future that will tell us whether BRIDGE works well. BPD is characterised by long standing difficulty in managing emotional responses, personal relationships, impulse control and self-image. Research shows that individuals with BPD may experience discrimination and resulting stigmatisation by both the public and health care professionals. Many adolescents and young people with complex needs and high suicide risk are left under-diagnosed and untreated. As a result, young people with BPD are frequently not in education or training and experience challenging relationships with friends and families. The overall aim of the study is to assess the possibility of providing a treatment programme for young people with BPD symptoms in the general population, who may or may not be accessing any mental health services. First, we need to see whether young people are comfortable with random allocation to BRIDGE (AND service as usual) or Service-as-usual (ALONE) (a bit like tossing a coin). Second, we need to find out whether enough young people want to be involved. Third, whether we can find out the information we need about them and can follow up enough young people later. The proposed study will try to find these things out, so that we can design a future, bigger, study to find out whether BRIDGE is good value for young people with BPD.
277 studies on the registry are indexed under Borderline Personality Disorder; 68 are open to participants now.
This study's planned enrollment of 60 is below the median of 70 across 222 interventional studies indexed under Borderline Personality Disorder.
Browse Borderline Personality Disorder studies →NHS Greater Glasgow and Clyde is the lead sponsor of 220 studies on the registry; 39 are open to participants now.
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Exclusion Criteria:
Brief, intensive assessment and integrated formulation (BRIDGE) intervention is guided by the evidence base of Cognitive Analytic Therapy (CAT) with young people (aged 14-25) with features of BPD using an early intervention model and in collaboration with an established Glasgow programme, Intensive Support and Monitoring Service (ISMS). ISMS focuses on reaching a shared formulation with the young person and the multi-agency system that supports them. BRIDGE is delivered over 3-6 months and includes :- an intensive assessment, including BPD symptoms, copresenting difficulties, neurodevelopmental profile, life events history and psychosocial functioning; up to 16 sessions of Cognitive Analytic Therapy (CAT) and the development of a shared formulation with a multi-agency group. Further development of this formulation with the young person, using CAT principles (Reformulation, Recognition and Revision) and, where clinically applicable, their family and service-providers.
Behavioral: BRIDGE Intervention · Behavioral: Service as Usual
Services as Usual (SAU) For participants randomised to SAU, a routine letter of their participation will be shared with their service provider(s), including their GP. SAU, is likely to range from social services, mental-health services, forensic services to no services in some cases. Pathways to care and service involvement will be mapped and described for each participant. Treatment fidelity to SAU will therefore not be assessed, but the nature and intensity of SAU in different contexts will be described in detail through the qualitative process evaluation.
Behavioral: Service as Usual
Intensive clinical assessment; \>16 sessions of Cognitive Analytic Therapy (CAT); Development of a shared formulation
Likely to range from social services, mental-health services, forensic services to no intervention
Recruitment & Retention rates
The number of participants recruited for randomisation and the number retained to follow-up (12 \& 24wks post randomisation).
Time frame: Continuous over 3 year study period
Acceptability of trial processes and interventions
Explored through qualitative interviews
Time frame: Continuous over 3 year study period
Process Evaluation
Theory of change and logic modelling will be explored to capture the process behind intervention effects.
Time frame: Continuous over 3 year study period
Structured Clinical Interview for DSM-IV Personality Disorders (SCID-II) PQ-BPD
15 Item Questionnaire for Borderline Personality Disorder
Time frame: Screening; Pre-randomisation
Structured Clinical Interview for DSM-IV Personality Disorders (SCID-II) DSM-V
Clinical interview using the SCID-II DSM-V
Time frame: Screening/Pre-randomisation
KIDSCREEN-10 Index
Health Questionnaire for Children and Young People
Time frame: Screening/Pre-randomisation
KIDDIE Schedule for Affective Disorders and Schizophrenia Present and Lifetime Version (K-SADS-PL)
Questionnaire for affective disorders and schizophrenia
Time frame: within 2 weeks of randomisation (baseline)
Adverse Childhood Experiences Scale
Questionnaire for Adverse Childhood Experiences
Time frame: within 2 weeks of randomisation (baseline)
The Autism Symptom Self Report for Adolescents (ASSERT) Scale
Questionnaire for symptoms of Autism
Time frame: within 2 weeks of randomisation (baseline)
Adult ADHD Self-Report Scale (ASRS)
Questionnaire for ADHD symptoms in adulthood
Time frame: within 2 weeks of randomisation (baseline)
Borderline Symptoms List (BSL)
Questionnaire for symptoms of Borderline Personality Disorder (BPD)
Time frame: Baseline and Follow-up (12 and 24weeks post randomisation)
Sheehan's Disability Scale (SDS)
Assessment of functional impairment
Time frame: Baseline and Follow-up (12 and 24weeks post randomisation)
Difficulties in Emotional Regulation Scale-Short Form (DERS-SF)
Questionnaire to assess emotion regulation
Time frame: Baseline and Follow-up (12 and 24weeks post randomisation)
Patient Health Questionnaire-9 (PHQ-9)
General health questionnaire
Time frame: Baseline and Follow-up (12 and 24weeks post randomisation)
EuroQol-5D-5L (EQ-5D-5L)
Quality of Life questionnaire
Time frame: Baseline and Follow-up (12 and 24weeks post randomisation)
Suicidal Ideation Scale
Questionnaire for suicidal ideation
Time frame: Baseline and Follow-up (12 and 24weeks post randomisation)
Vocational and Educational Functioning
Measure of functioning in domains of work and education
Time frame: Baseline and Follow-up (12 and 24weeks post randomisation)
Documents are hosted by the registry — open the source record to download them.
Plan to share: No — The PI will manage access rights to the data set. We anticipate that anonymised trial data may be shared with other researchers to contribute to the emerging BPD evidence base.
This study is status unknown, as verified in Apr 2024. You cannot join it, but the record below documents what was studied.
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Borderline Personality Disorder →
NHS Greater Glasgow and Clyde →