An interventional study of beetroot juice and nitrate in Hypertension, sponsored by Poznan University of Physical Education. Enrolling by invitation at 1 site in Poland. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-11-15.
Sponsored by Poznan University of Physical Education · Not applicable, Interventional, and Prevention
The primary aim of the current study is to determine the effect of beetroot juice consumption on plasma trimethylamine N-oxide concentration.
A secondary aims: exploring the effect of circulating trimethylamine N-oxide modification on plasma total antioxidant status, and measurement of changes in the skin nicotinamide-adenine dinucleotide reduced form (NADH) content during transient ischemia and reperfusion.
In a random order subjects will consume beetroot juice (140ml), or equimolar nitrates (NaNO3). Antecubital vein blood samples will be taken at the beginning, and every hour for 4 hours following consumption.
Plasma trimethylamine N-oxide, total antioxidant status, and nitrite/nitrate concentrations will be determined.
Using Flow Mediated Skin Fluorescence skin NADH content determined during controlled ischemia triggered by total occlusion of the brachial artery by the brachial blood pressure cuff and during reperfusion after deflation of the blood pressure cuff 2 and 4 hours following consumption.
6,690 studies on the registry are indexed under Hypertension; 966 are open to participants now.
This study's planned enrollment of 20 is below the median of 90 across 4,996 interventional studies indexed under Hypertension.
Browse Hypertension studies →Poznan University of Physical Education is the lead sponsor of 90 studies on the registry; 27 are open to participants now.
Counted across the registry records on this site, refreshed daily.
healthy volunteers
Exclusion Criteria:
single intake of beetroot juice containing 800mg nitrates
Dietary Supplement: beetroot juice
single intake of 800mg nitrates (NaNO3)
Other: nitrate
single intake of beetroot juice containing 800mg nitrates
Also known as: 140 ml of Beet It juice
single intake of 800mg nitrates
Also known as: NaNO3
The effect of beetroot juice consumption on plasma trimethylamine N-oxide concentration
Determination of plasma trimethylamine N-oxide concentration following the beetroot juice consumption using ultra performance liquid chromatography - tandem mass spectrometer (UPLC-MS/MS) method.
Time frame: 4 hours
The effect of circulating trimethylamine N-oxide modification on plasma total antioxidant status
Determination of plasma total antioxidant status following the beetroot juice consumption using commercially available kit.
Time frame: 4 hours
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Poznan University of Physical Education